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PIP4K2C and BTK
Number of citations of the paper that reports this interaction (PMID
15046600
)
4
Data Source:
HPRD
(in vivo, in vitro)
PIP4K2C
BTK
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Bruton agammaglobulinemia tyrosine kinase
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Membrane
Extracellular Vesicular Exosome
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cytoplasmic Vesicle
Mast Cell Granule
Intracellular Membrane-bounded Organelle
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
ATP Binding
1-phosphatidylinositol-5-phosphate 4-kinase Activity
Identical Protein Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Phosphatidylinositol Phosphorylation
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Histamine Secretion By Mast Cell
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Transcription, DNA-templated
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Mesoderm Development
Calcium-mediated Signaling
Cell Differentiation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
B Cell Activation
Regulation Of Cell Proliferation
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Cell Maturation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Pathways
Signaling by the B Cell Receptor (BCR)
DAP12 interactions
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll Like Receptor TLR1:TLR2 Cascade
DAP12 signaling
Activated TLR4 signalling
Toll-Like Receptors Cascades
Toll Like Receptor 4 (TLR4) Cascade
Fc epsilon receptor (FCERI) signaling
MyD88:Mal cascade initiated on plasma membrane
FCERI mediated Ca+2 mobilization
Fcgamma receptor (FCGR) dependent phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Regulation of actin dynamics for phagocytic cup formation
Adaptive Immune System
Innate Immune System
Drugs
Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS
Rheumatoid arthritis (
18794853
)
Protein-Protein Interactions
3 interactors:
APP
BTK
FBXO25
64 interactors:
ABL1
APP
ARHGAP17
ARID3A
ARRB1
BCL2L11
BLNK
BMX
CAV1
CBL
CD19
CMTM3
DAPP1
EWSR1
FAS
FASLG
FYN
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MYD88
PIK3AP1
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
Entrez ID
79837
695
HPRD ID
15138
02248
Ensembl ID
ENSG00000166908
ENSG00000010671
Uniprot IDs
B3KQV3
Q8TBX8
Q06187
Q5JY90
PDB IDs
2GK9
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
Enriched GO Terms of Interacting Partners
?
Cell Maturation
Regulation Of B Cell Cytokine Production
Cellular Response To Molecule Of Fungal Origin
Synaptic Growth At Neuromuscular Junction
Collateral Sprouting In Absence Of Injury
Response To Molecule Of Fungal Origin
Collateral Sprouting
Axon Midline Choice Point Recognition
Exocytosis
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Response To Oxidative Stress
Neuron Remodeling
Secretion By Cell
Histamine Secretion By Mast Cell
Histamine Secretion
Positive Regulation Of B Cell Differentiation
Secretion
Histamine Transport
Cellular Copper Ion Homeostasis
Regulation Of B Cell Apoptotic Process
Cell Activation
Cellular Protein Modification Process
Copper Ion Homeostasis
Suckling Behavior
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mast Cell Degranulation
Innate Immune Response
Production Of Molecular Mediator Involved In Inflammatory Response
Neuron Maturation
MRNA Polyadenylation
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Regulation Of B Cell Differentiation
Mast Cell Mediated Immunity
Mating Behavior
Lysosome Localization
Mast Cell Activation
Endoplasmic Reticulum Calcium Ion Homeostasis
RNA Polyadenylation
Neuron Recognition
Peptidyl-tyrosine Autophosphorylation
Apoptotic Process
B Cell Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Response To Fungus
Leukocyte Degranulation
Programmed Cell Death
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cell Death
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response-regulating Signaling Pathway
Intracellular Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Signal Transduction
Immune System Process
Signaling
Cell Surface Receptor Signaling Pathway
Cell Communication
Regulation Of Immune Response
Regulation Of Immune System Process
Positive Regulation Of Immune Response
Positive Regulation Of Immune System Process
Innate Immune Response
Immune Response
Cellular Response To Stimulus
Blood Coagulation
Hemostasis
Cell Activation
Response To Stress
Defense Response
Positive Regulation Of Signal Transduction
Regulation Of Body Fluid Levels
Wound Healing
Regulation Of Signal Transduction
Response To Wounding
Positive Regulation Of Intracellular Signal Transduction
Response To External Stimulus
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Response To Stimulus
Fc Receptor Signaling Pathway
Regulation Of Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Platelet Activation
Regulation Of Intracellular Signal Transduction
Antigen Receptor-mediated Signaling Pathway
Response To Organic Substance
Phosphorylation
Cellular Response To Organic Substance
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Metabolic Process
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Cytokine Biosynthetic Process
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Leukocyte Activation
Protein Autophosphorylation
Tagcloud
?
adhesion
allergic
appear
asthma
compares
contrasts
csf
degranulation
describes
emerging
eosinophil
eosinophils
exert
gm
granulocyte
hematopoiesis
heterodimer
jak
lyn
macrophage
paramount
propagates
raf
segregation
seminal
shp
stat
syk
transduction
Tagcloud (Difference)
?
adhesion
allergic
appear
asthma
compares
contrasts
csf
degranulation
describes
emerging
eosinophil
eosinophils
exert
gm
granulocyte
hematopoiesis
heterodimer
jak
lyn
macrophage
paramount
propagates
raf
segregation
seminal
shp
stat
syk
transduction
Tagcloud (Intersection)
?