PIP4K2C

Description		phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Identical Protein Binding Phosphatidylinositol Kinase Activity
	Biological Process	Lipid Metabolic Process Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs		Fostamatinib
Diseases
GWAS		Rheumatoid arthritis ( 18794853)
Novel Interacting Genes		1 novel interacting genes: INHBE
Interacting Genes		5 interacting genes: APP BTK FBXO25 OGT PJA1
Entrez ID		79837
HPRD ID		15138
Ensembl ID		ENSG00000166908
Uniprot IDs		B3KQV3 Q8TBX8
PDB IDs		2GK9 7QIE 7QPN 8BQ4
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Toll Signaling Pathway Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Phosphatidylinositol-3,4,5-trisphosphate Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Protein Metabolic Process Positive Regulation Of Inflammatory Response Calcium-mediated Signaling Axon Midline Choice Point Recognition Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6 Production Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Positive Regulation Of Amyloid Fibril Formation Cell Maturation Regulation Of Interleukin-6 Production Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Generation Of Precursor Metabolites And Energy
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