FBXO31 and GHR

Number of citations of the paper that reports this interaction (PubMedID 25505247)
55

Data Source:
BioGRID (unspecified method)

		FBXO31	GHR
Description		F-box protein 31	growth hormone receptor
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex Neuronal Cell Body	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Protein Binding Cyclin Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	DNA Damage Response Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress P38MAPK Cascade Signal Transduction In Response To DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Brain morphology (MOSTest) ( 32665545) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)	Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2	44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		79791	2690
HPRD ID		10954	02971
Ensembl ID		ENSG00000103264	ENSG00000112964
Uniprot IDs		A0A0C4DGU8 Q5XUX0	A0A087X0H5 A0A087X162 P10912
PDB IDs		5VZT 5VZU	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Alcohol Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To Nutrient Levels Positive Regulation Of Mitotic Cell Cycle Response To UV-A Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Response To Hormone Response To Growth Hormone Response To Magnesium Ion Cellular Response To Peptide Hormone Stimulus Proline-rich Region Binding Regulation Of Cell Cycle G1/S Phase Transition Response To Ether Regulation Of Cell Cycle Process Response To Ketone Negative Regulation Of Protein Maturation Response To Steroid Hormone Response To Lipid Response To Food Positive Regulation Of Cell Cycle Process Response To Iron Ion Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Response To Peptide Hormone Response To Metal Ion Response To Light Stimulus Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Hormone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Regulation Of Protein Maturation Response To Estrogen Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response Response To Radiation Positive Regulation Of Developmental Process Protein Kinase Binding Response To Vitamin Proteasomal Protein Catabolic Process Animal Organ Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Cell Proliferation	Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm
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