FBXO31 and CDT1

Number of citations of the paper that reports this interaction (PubMedID 24828503)
47

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		FBXO31	CDT1
Description		F-box protein 31	chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex Neuronal Cell Body	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Protein Binding Cyclin Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	DNA Damage Response Protein Ubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress P38MAPK Cascade Signal Transduction In Response To DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)	Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2	27 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		79791	81620
HPRD ID		10954	06900
Ensembl ID		ENSG00000103264	ENSG00000167513
Uniprot IDs		A0A0C4DGU8 Q5XUX0	Q9H211
PDB IDs		5VZT 5VZU	2LE8 2WVR 6QCG 8RWV 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Alcohol Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To Nutrient Levels Positive Regulation Of Mitotic Cell Cycle Response To UV-A Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To UV Response To Hormone Response To Growth Hormone Response To Magnesium Ion Cellular Response To Peptide Hormone Stimulus Proline-rich Region Binding Regulation Of Cell Cycle G1/S Phase Transition Response To Ether Regulation Of Cell Cycle Process Response To Ketone Negative Regulation Of Protein Maturation Response To Steroid Hormone Response To Lipid Response To Food Positive Regulation Of Cell Cycle Process Response To Iron Ion Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Response To Peptide Hormone Response To Metal Ion Response To Light Stimulus Positive Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Hormone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Enzyme Binding Regulation Of Protein Maturation Response To Estrogen Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response Response To Radiation Positive Regulation Of Developmental Process Protein Kinase Binding Response To Vitamin Proteasomal Protein Catabolic Process Animal Organ Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Smooth Muscle Cell Proliferation	Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex
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