SNIP1 and SETDB1

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SNIP1	SETDB1
Gene Name		Smad nuclear interacting protein 1	SET domain, bifurcated 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Poly(A) RNA Binding	DNA Binding Protein Binding Zinc Ion Binding Histone-lysine N-methyltransferase Activity
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Kinase/NF-kappaB Signaling Production Of MiRNAs Involved In Gene Silencing By MiRNA	Negative Regulation Of Transcription From RNA Polymerase II Promoter Inner Cell Mass Cell Proliferation Chromatin Organization Transcription, DNA-templated Histone H3-K9 Trimethylation Bone Development
Pathways			Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Melanoma ( 21983785)
Protein-Protein Interactions		40 interactors: C17orf85 CDK6 CHERP CLK2 CREBBP DVL2 EIF3C EP300 FAF1 GMEB1 HIPK1 HIPK3 MAX MFAP1 MYC PIAS1 PIAS2 PIAS4 PRPF3 PRPF40A RELA SETDB1 SF3B1 SMAD1 SMAD2 SMAD4 SON SP100 SRPK2 SRRM2 TDG TNIP1 TOPORS TTC14 UBE2I ZCCHC10 ZCCHC7 ZMYM2 ZMYM5 ZNF451	107 interactors: AIFM1 AKT1 ANXA7 APC APLP1 ASAH1 ATF7IP ATF7IP2 BAG6 BARD1 BHLHE40 BID BRIX1 BTBD2 C11orf1 CBX8 CCDC106 CDK4 CDKN1A CLSTN1 CRELD1 DAP DLEU1 DNMT3A ECSIT ERG ERH FAM118B FLYWCH1 GIPC2 GPS2 GRB7 GSTO1 HDAC1 HDAC2 HIST1H3A HIST2H3A HIST3H3 HIST4H4 HMOX2 HSPB3 JARID2 KDM1A LRIF1 LUC7L2 MAD2L1BP MAP4K5 MBD1 MDM2 MOB4 MRPL44 MZT2B NIPSNAP3A OLFML3 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PGAM5 PHF10 PIAS4 PLEKHA4 POLA2 PPA1 PPARG PPP1R8 PRKRA PSMD11 PSME1 PTPRS QTRT1 RIF1 RNF10 S100A10 SAT1 SERPINB9 SIN3A SIN3B SKIL SLC38A3 SMN1 SNIP1 SUFU SULT1E1 SUMO2 TARDBP TCERG1 THAP8 TK1 TOB1 TOLLIP TPI1 TRBV2 TRDMT1 TRIB3 TRIM16 TRIM28 TSC22D1 TTR TXNDC9 UBE2I ULK2 USP11 VIM ZFP64 ZNF24
Entrez ID		79753	9869
HPRD ID		06999	06828
Ensembl ID		ENSG00000163877	ENSG00000143379
Uniprot IDs		B1AK66 Q8TAD8	Q15047
PDB IDs			3DLM
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Protein Sumoylation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-lysine Modification Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Processing Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Regulation Of Cell Proliferation SMAD Protein Complex Assembly Peptidyl-amino Acid Modification Positive Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signaling Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Cellular Metabolic Process N-terminal Peptidyl-lysine Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Regulation Of Cell Death	Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process DNA Methylation Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Chromosome Organization Regulation Of RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Transcription, DNA-templated Regulation Of Proteolysis DNA Modification Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Protein Metabolic Process Chromatin Organization Positive Regulation Of Metabolic Process Response To Stress Transcription, DNA-templated Gene Silencing Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Chromatin Silencing Metabolic Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Cell Cycle
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended gli2 h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve suppresses tumorigenic turn	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended gli2 h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve suppresses tumorigenic turn	adversely astrocytic astroglial chaetocin clarified clinicopathological clonogenic correlating deregulation emerges glioblastomas gliomagenesis grades h1x h3k9 h3k9me3 h4k20me3 immunoblotting implicates inversely linker methyltransferases migratory pathobiology prognosticator reportedly suv39h1 t98g verified
Tagcloud (Intersection) ?