SNIP1 and NFATC2

		SNIP1	NFATC2
Description		Smad nuclear interacting protein 1	nuclear factor of activated T cells 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2 SnRNP Cytosol U2-type Precatalytic Spliceosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Transcription Factor AP-1 Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Transcription Regulator Inhibitor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Phosphatase Binding Sequence-specific DNA Binding Molecular Adaptor Activity 14-3-3 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing MiRNA Processing Negative Regulation Of Canonical NF-kappaB Signal Transduction U2-type Prespliceosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA Damage Response Response To Xenobiotic Stimulus Gene Expression Positive Regulation Of Gene Expression Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Cartilage Development Cellular Response To Calcium Ion LncRNA Transcription Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		mRNA Splicing - Major Pathway	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Axial length ( 24144296) Eyebrow thickness ( 26926045)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Height ( 28552196) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 30718926 32499647) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)
Interacting Genes		47 interacting genes: CDK6 CREBBP DVL2 DVL3 EIF3C EP300 ESRRG FAF1 GMEB1 GYS1 HIPK1 HIPK3 KRTAP10-6 MAX MYC PHF19 PIAS1 PIAS2 PIAS3 PIAS4 POU2F1 PRPF3 PRPF40A RELA SETDB1 SF3B1 SMAD1 SMAD2 SMAD4 SON SP100 SPANXN2 SRPK2 SRRM4 STK3 TDG TNIP1 TOPORS TSPYL2 TTC14 UBE2I ZBTB9 ZCCHC10 ZCCHC7 ZMYM2 ZMYM5 ZNF451	20 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP NRON PIN1 PPP3CB PPP3R1 PRKCZ SOCS3 TAF9 VIM YWHAQ YWHAZ
Entrez ID		79753	4773
HPRD ID		06999	02730
Ensembl ID		ENSG00000163877	ENSG00000101096
Uniprot IDs		B1AK66 Q8TAD8	B5B2P4 Q13469
PDB IDs		5Z56 5Z57 5Z58 6FF7 7ABG 7ABH 7ABI 7DVQ 8I0P 8I0R	1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF 8OW4 8R07 8R3F
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process PML Body Chromatin Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process SUMO Transferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Sumoylation SUMO Ligase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Activity Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of MiRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Transcription Regulator Complex DNA-binding Transcription Factor Binding Nuclear Speck DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Regulation Of MiRNA Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Metabolic Process Regulation Of MiRNA Metabolic Process Nucleobase-containing Compound Metabolic Process	Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Biosynthetic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of RNA Metabolic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Macromolecule Metabolic Process T Cell Lineage Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of T-helper Cell Differentiation T-helper 17 Cell Lineage Commitment Positive Regulation Of Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Localization To Nucleus T-helper Cell Lineage Commitment Histone H3K27 Acetyltransferase Activity Mononuclear Cell Differentiation DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of CD4-positive, Alpha-beta T Cell Activation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Interleukin-4 Production Leukocyte Differentiation Histone Acetyltransferase Activity Regulation Of Interleukin-4 Production Lymphocyte Differentiation Lymphocyte Activation Regulation Of Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Tau Protein Binding Phosphoserine Residue Binding Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cell Differentiation
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