SNIP1 and EIF3C

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		SNIP1	EIF3C
Gene Name		Smad nuclear interacting protein 1	eukaryotic translation initiation factor 3, subunit C
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding	Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated I-kappaB Kinase/NF-kappaB Signaling Production Of MiRNAs Involved In Gene Silencing By MiRNA	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process
Pathways			Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Inflammatory bowel disease (early onset) ( 19915574)
Protein-Protein Interactions		40 interactors: C17orf85 CDK6 CHERP CLK2 CREBBP DVL2 EIF3C EP300 FAF1 GMEB1 HIPK1 HIPK3 MAX MFAP1 MYC PIAS1 PIAS2 PIAS4 PRPF3 PRPF40A RELA SETDB1 SF3B1 SMAD1 SMAD2 SMAD4 SON SP100 SRPK2 SRRM2 TDG TNIP1 TOPORS TTC14 UBE2I ZCCHC10 ZCCHC7 ZMYM2 ZMYM5 ZNF451	15 interactors: AAGAB CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K HMOX2 MAPK6 NDUFA4L2 PFDN1 RPS6KA3 SMAD9 SNIP1 UBC
Entrez ID		79753	8663
HPRD ID		06999	04889
Ensembl ID		ENSG00000163877	ENSG00000184110
Uniprot IDs		B1AK66 Q8TAD8	H3BRV0 Q99613
PDB IDs
Enriched GO Terms of Interacting Partners?		Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Protein Sumoylation Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Peptidyl-lysine Modification Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Processing Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Regulation Of Cell Proliferation SMAD Protein Complex Assembly Peptidyl-amino Acid Modification Positive Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signaling Transcription From RNA Polymerase II Promoter Pattern Specification Process Positive Regulation Of Cellular Metabolic Process N-terminal Peptidyl-lysine Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Intracellular Signal Transduction Regulation Of Cell Death	Formation Of Translation Preinitiation Complex Regulation Of Translational Initiation Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Translation Ribonucleoprotein Complex Assembly Cellular Protein Metabolic Process Translation Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Metabolic Process Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Gene Expression Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus MAPK Cascade Response To Growth Factor Intracellular Signal Transduction Cellular Macromolecular Complex Assembly Toll-like Receptor 5 Signaling Pathway Regulation Of Gene Expression Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Signal Transduction By Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Glycogen Metabolic Process Response To Hypoxia TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Midbrain Development Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Heme Oxidation Toll-like Receptor Signaling Pathway Central Nervous System Development Stress-activated MAPK Cascade Cellular Macromolecule Biosynthetic Process Stress-activated Protein Kinase Signaling Cascade Immune Response-regulating Signaling Pathway
Tagcloud ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended gli2 h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve suppresses tumorigenic turn	adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Difference) ?		activates bcar4 ccl21 chemokine consequences consisting coordinated correlates enables extended gli2 h3k18ac hedgehog indirect lnas lncrna lncrnas locked noncanonical nucleic pnuts pol pp1 recruited releases relieve suppresses tumorigenic turn	adr alternatively b16f10 deliver emphasize eukaryote eventually evolving g0 gep hct116 housekeeping hyaluronan kind lnps manipulating mcf7 nar nci polysome res retrieved rnai run seeking sirnas ubiquitously unstable vital
Tagcloud (Intersection) ?