KCTD17 and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		KCTD17	TINF2
Gene Name		potassium channel tetramerization domain containing 17	TERF1 (TRF1)-interacting nuclear factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Protein Homooligomerization	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		12 interactors: AQP1 DMC1 LNX1 LRRC18 NIF3L1 NUDT18 PSMA1 RWDD4 STK16 SUV39H2 TINF2 TUBGCP4	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		79734	26277
HPRD ID		07764	16056
Ensembl ID		ENSG00000100379	ENSG00000092330
Uniprot IDs		Q8N5Z5	B4DFJ1 Q9BSI4
PDB IDs			3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Male Meiosis Negative Regulation Of Protein ADP-ribosylation Metanephric Descending Thin Limb Development DGDP Catabolic Process Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development DADP Catabolic Process Maintenance Of Symbiont-containing Vacuole By Host Transepithelial Water Transport GDP Catabolic Process Response To Brefeldin A Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein ADP-ribosylation Carbon Dioxide Transmembrane Transport Corticotropin Secretion 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Establishment Or Maintenance Of Actin Cytoskeleton Polarity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Oxygen Levels Metanephric Proximal Convoluted Tubule Development Nitric Oxide Transport Dihydrobiopterin Metabolic Process Cellular Response To Mercury Ion Cell Cycle Metanephric Proximal Tubule Development Negative Regulation Of Protein Glycosylation Renal Water Absorption Histone H3-K9 Dimethylation Positive Regulation Of Saliva Secretion Carbon Dioxide Transport Epithelial Fluid Transport Meiotic Nuclear Division Protein Localization To Chromosome, Telomeric Region Purine Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Renal Water Transport Cellular Response To Copper Ion Nucleobase-containing Small Molecule Catabolic Process Pancreatic Juice Secretion Telomere Assembly Proximal Tubule Development Regulation Of Saliva Secretion Cellular Metabolic Process Ribonucleoside Diphosphate Catabolic Process Metanephric Loop Of Henle Development Cerebrospinal Fluid Secretion	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		57r arrests aurora axoneme centriolar centrioles cilia ciliary ciliogenesis crl3 crl3s cul3 developments doublet exit extension initiate instructive k50 ligases mother multistep organelles organize polyubiquitylates removes stepped trichoplein ubiquitylatable	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		57r arrests aurora axoneme centriolar centrioles cilia ciliary ciliogenesis crl3 crl3s cul3 developments doublet exit extension initiate instructive k50 ligases mother multistep organelles organize polyubiquitylates removes stepped trichoplein ubiquitylatable	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?