KCTD17 and RWDD4

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		KCTD17	RWDD4
Description		potassium channel tetramerization domain containing 17	RWD domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Hemoglobin levels ( 33491795) Iron status biomarkers (ferritin levels) ( 28334935) Liver iron content ( 34128465) Mean corpuscular hemoglobin concentration ( 28453575) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell traits ( 23222517)
Interacting Genes		23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1	3 interacting genes: BRCA1 FBXO7 KCTD17
Entrez ID		79734	201965
HPRD ID		07764	14393
Ensembl ID		ENSG00000100379	ENSG00000182552
Uniprot IDs		A0A087WX35 Q8N5Z5	E7EV43 Q6NW29
PDB IDs		5A6R
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding	Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Histone H2AK127 Ubiquitin Ligase Activity Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Lewy Body Core BRCA1-B Complex Ubiquitin-protein Transferase Activity Regulation Of Organelle Assembly Protein Polyubiquitination Negative Regulation Of Cell Cycle Process Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Response To Indole-3-methanol Ubiquitin Protein Ligase Binding Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Centriole Replication Negative Regulation Of Cell Cycle BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Regulation Of Apoptotic Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Centrosome Duplication XY Body Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Regulation Of Cell Cycle Phase Transition DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Proteasomal Protein Catabolic Process Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Ubiquitin-dependent Protein Catabolic Process RNA Polymerase Binding Modification-dependent Protein Catabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Sex-chromosome Dosage Compensation
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