KCTD17 and DMC1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		KCTD17	DMC1
Description		potassium channel tetramerization domain containing 17	DNA meiotic recombinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex	Chromosome, Telomeric Region Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding Catalytic Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation DNA Metabolic Process DNA Repair Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Gamete Generation Spermatogenesis Spermatid Development Female Gamete Generation DNA Strand Invasion Oogenesis Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination
Pathways			Meiotic recombination Meiotic recombination
Drugs			Imidazole
Diseases
GWAS		Hemoglobin levels ( 33491795) Iron status biomarkers (ferritin levels) ( 28334935) Liver iron content ( 34128465) Mean corpuscular hemoglobin concentration ( 28453575) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell traits ( 23222517)	Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1	20 interacting genes: BRCA2 FIGNL1 FIRRM GORASP2 KCTD17 LNX1 MCPH1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I
Entrez ID		79734	11144
HPRD ID		07764	04099
Ensembl ID		ENSG00000100379	ENSG00000100206
Uniprot IDs		A0A087WX35 Q8N5Z5	Q14565
PDB IDs		5A6R	1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY 8QQE 8R2G
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding	Recombinational Repair Lateral Element Double-strand Break Repair Via Homologous Recombination Response To Ionizing Radiation DNA Recombination Mitotic Recombination-dependent Replication Fork Processing DNA Repair Mitotic Recombination Cellular Response To Ionizing Radiation Cellular Response To Stress Reciprocal Meiotic Recombination Double-strand Break Repair Nuclear Chromosome Single-stranded DNA Binding PML Body Identical Protein Binding Condensed Chromosome Meiotic Cell Cycle Homologous Recombination DNA Metabolic Process Interstrand Cross-link Repair Nuclear Ubiquitin Ligase Complex DNA Damage Response Condensed Nuclear Chromosome Cellular Response To Radiation Chromosome, Telomeric Region Reproductive Process Meiotic Nuclear Division Macromolecule Metabolic Process Telomere Maintenance Via Recombination Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Division ATP-dependent DNA Damage Sensor Activity Telomere Maintenance SUMO Transferase Activity Response To Stress Regulation Of DNA Damage Checkpoint Synaptonemal Complex Nucleoplasm Telomere Organization Response To X-ray Double-stranded DNA Binding Mismatch Repair Regulation Of DNA Recombination Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nucleus Regulation Of Double-strand Break Repair Chromosome
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