PALB2 and BRCA2

Number of citations of the paper that reports this interaction (PMID 16793542)
147

Data Source:
HPRD (in vivo)

		PALB2	BRCA2
Gene Name		partner and localizer of BRCA2	breast cancer 2, early onset
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex
	Molecular Function	DNA Binding Protein Binding	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair Mesoderm Development Organ Morphogenesis Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication
Pathways		Fanconi Anemia pathway	Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		3 interactors: BRCA2 HNRNPC RAD51AP1	34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11
Entrez ID		79728	675
HPRD ID		07966	02554
Ensembl ID		ENSG00000083093	ENSG00000139618
Uniprot IDs		Q86YC2	P51587
PDB IDs		2W18 3EU7	1N0W 3EU7
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair DNA Recombination Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Response To Radiation 3'-UTR-mediated MRNA Stabilization Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Modification Regulation Of Mammary Gland Epithelial Cell Proliferation Chromatin Organization Inner Cell Mass Cell Proliferation Oocyte Maturation MRNA Stabilization Regulation Of Double-strand Break Repair Blastocyst Growth Cellular Response To DNA Damage Stimulus Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Chromosome Organization Histone H3 Acetylation Oocyte Development DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Histone H4 Acetylation Response To Gamma Radiation Regulation Of MRNA Stability Regulation Of RNA Stability Centrosome Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cytokinesis Cellular Response To Ionizing Radiation Male Meiosis Regulation Of DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination ATP-dependent Chromatin Remodeling Cell Aging	Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Difference) ?		alleles atm brip1 cdh1 chek2 contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	185delag 5677insa adriamycin breaks camptothecin cip1 clones doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1
Tagcloud (Intersection) ?		brca1 brca2 confer