PALB2 and USP22

Number of citations of the paper that reports this interaction (PubMedID 31685642)
56

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PALB2	USP22
Description		partner and localizer of BRCA2	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	SAGA Complex Nucleus Nucleoplasm Cytoplasm Transcription Factor TFTC Complex
	Molecular Function	DNA Binding Protein Binding	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Histone H4 Acetyltransferase Activity Hydrolase Activity Enzyme Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	G2/M Transition Of Mitotic Cell Cycle Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Proteolysis Embryo Development Ending In Birth Or Egg Hatching Protein Deubiquitination Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Mitotic Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	17 interacting genes: BAG4 CEBPA H2AC20 H2AC4 H2BC21 H2BC3 HEXA MRPL10 MRPL44 MTUS2 PALB2 PSME1 PTGS2 RCAN1 SCFD1 UBC ZEB1
Entrez ID		79728	23326
HPRD ID		07966	19411
Ensembl ID		ENSG00000083093	ENSG00000124422
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	Q9UPT9
PDB IDs		2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?