PALB2

Gene Name		partner and localizer of BRCA2
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Gene Ontology Annotations	Cellular Component	Nucleoplasm
	Molecular Function	DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair Mesoderm Development Organ Morphogenesis Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)
Protein-protein Interactions		3 interactors: BRCA2 HNRNPC RAD51AP1
Entrez ID		79728
HPRD ID		07966
Ensembl ID		ENSG00000083093
Uniprot IDs		Q86YC2
PDB IDs		2W18 3EU7
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair DNA Recombination Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Response To Radiation 3'-UTR-mediated MRNA Stabilization Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Modification Regulation Of Mammary Gland Epithelial Cell Proliferation Chromatin Organization Inner Cell Mass Cell Proliferation Oocyte Maturation MRNA Stabilization Regulation Of Double-strand Break Repair Blastocyst Growth Cellular Response To DNA Damage Stimulus Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Chromosome Organization Histone H3 Acetylation Oocyte Development DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Histone H4 Acetylation Response To Gamma Radiation Regulation Of MRNA Stability Regulation Of RNA Stability Centrosome Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cytokinesis Cellular Response To Ionizing Radiation Male Meiosis Regulation Of DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination ATP-dependent Chromatin Remodeling Cell Aging
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue