PALB2 and CST6

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PALB2	CST6
Description		partner and localizer of BRCA2	cystatin E/M
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	Cornified Envelope Extracellular Region Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Epidermis Development Anatomical Structure Morphogenesis
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	A body shape index ( 34021172) Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 31562340) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	7 interacting genes: BCAR3 GSK3B NOTCH2 PALB2 RAD51 TGFB1 YIF1A
Entrez ID		79728	1474
HPRD ID		07966	03535
Ensembl ID		ENSG00000083093	ENSG00000175315
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	Q15828
PDB IDs		2W18 3EU7 7S4A 8YAP	4N6L 4N6M 4N6N 4N6O 6FK0
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Enzyme-linked Receptor Protein Signaling Pathway NF-kappaB Binding Myeloid Dendritic Cell Activation Gland Morphogenesis Myeloid Dendritic Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Microtubule Anchoring At Centrosome Regulation Of Intracellular Signal Transduction Enzyme Binding Developmental Growth Regulation Of MiRNA Transcription Dendritic Cell Differentiation Positive Regulation Of MiRNA Metabolic Process Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of MiRNA Transcription Kidney Epithelium Development Positive Regulation Of Myeloid Leukocyte Differentiation Heart Valve Morphogenesis Positive Regulation Of Muscle Cell Differentiation Response To Xenobiotic Stimulus Response To Glucoside Cellular Response To Ionizing Radiation Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Canonical Wnt Signaling Pathway Negative Regulation Of Mesenchymal Stem Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Glycogen (starch) Synthase Activity Epithelial To Mesenchymal Transition Positive Regulation Of Intracellular Protein Transport Mesenchymal Cell Differentiation Insulin Receptor Signaling Pathway Tissue Remodeling Cholangiocyte Proliferation Multicellular Organism Growth Regulation Of MiRNA Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Myeloid Cell Differentiation Intrahepatic Bile Duct Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Liver Development Liver Morphogenesis Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Positive Regulation Of Primary MiRNA Processing
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