PALB2 and PDS5B

Number of citations of the paper that reports this interaction (PubMedID 27924011)
43

Data Source:
BioGRID (pull down)

		PALB2	PDS5B
Description		partner and localizer of BRCA2	PDS5 cohesin associated factor B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Protein Binding	DNA Binding Protein Binding Cohesin Unloader Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway	Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Liver enzyme levels (alanine transaminase) ( 33972514) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	7 interacting genes: APP BRCA2 CEBPA CFTR HASPIN PALB2 RAD51
Entrez ID		79728	23047
HPRD ID		07966	05624
Ensembl ID		ENSG00000083093	ENSG00000083642
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	Q9NTI5
PDB IDs		2W18 3EU7 7S4A 8YAP	5HDT
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Protein-containing Complex Mitotic Recombination-dependent Replication Fork Processing Cell Maturation Developmental Maturation Nuclear Ubiquitin Ligase Complex Lateral Element Telomere Maintenance Via Recombination DNA Repair Complex Regulation Of Cell Cycle Double-strand Break Repair Via Homologous Recombination Inner Cell Mass Cell Proliferation Recombinational Repair Mitotic Recombination Regulation Of DNA Damage Checkpoint Hematopoietic Stem Cell Proliferation Response To X-ray Double-strand Break Repair DNA Recombination Replication Fork Processing Meiosis I Cellular Response To Stress Response To Gamma Radiation Response To Stress Cellular Response To CAMP Chromosome Organization Amyloid-beta Complex Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Meiosis I Cell Cycle Process Meiotic Nuclear Division BRCA2-MAGE-D1 Complex Cellular Response To Ionizing Radiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Glucoside Stem Cell Proliferation DNA Binding Response To Radiation Response To CAMP Nuclear Division Regulation Of Cell Cycle Phase Transition Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Chromatin Binding
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