BRCA2 and BCCIP

Number of citations of the paper that reports this interaction (PMID 11313963)
26

Data Source:
HPRD (in vivo, two hybrid)

		BRCA2	BCCIP
Gene Name		breast cancer 2, early onset	BRCA2 and CDKN1A interacting protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex	Nucleus Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding	Protein Binding Kinase Regulator Activity Poly(A) RNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity DNA Repair Cell Cycle Neuroendocrine Cell Differentiation
Pathways		Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11	13 interactors: ABCB1 BARD1 BRCA2 CAPZB CCDC33 CDKN1A CSNK2B FAM46A HIST1H2BN ITSN2 PTN RAD51 RPL23
Entrez ID		675	56647
HPRD ID		02554	16542
Ensembl ID		ENSG00000139618	ENSG00000107949
Uniprot IDs		P51587	B4DUS0 B4E318 Q9P287
PDB IDs		1N0W 3EU7
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process	Cell Cycle Response To Ionizing Radiation Cell Cycle Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Ionizing Radiation Cellular Response To DNA Damage Stimulus Cell Aging Double-strand Break Repair Via Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Recombinational Repair Signal Transduction In Response To DNA Damage Negative Regulation Of MRNA 3'-end Processing Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Meiosis I DNA-dependent DNA Replication Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Ligation Cellular Response To Camptothecin G2/M Transition Of Mitotic Cell Cycle Response To Camptothecin Response To UV Cellular Response To Radiation Cell Cycle Arrest DNA Recombinase Assembly Intestinal Epithelial Cell Maturation Double-strand Break Repair Cell Maturation DNA Repair Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Filopodium Assembly Xenobiotic Transport Protein-DNA Complex Assembly Meiotic Nuclear Division Negative Regulation Of Protein Export From Nucleus Cellular Macromolecular Complex Assembly Positive Regulation Of Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Protein K6-linked Ubiquitination Cellular Response To UV-B Replication Fork Protection Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Proliferation Adiponectin-activated Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Ribosomal Protein Import Into Nucleus Regulation Of Cell Proliferation Meiotic Cell Cycle
Tagcloud ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	abundantly albeit antagonizes fbp fbp1 fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored stably suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Difference) ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	abundantly albeit antagonizes fbp fbp1 fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Intersection) ?		stably