PALB2 and GREB1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PALB2	GREB1
Description		partner and localizer of BRCA2	growth regulating estrogen receptor binding 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	Nucleoplasm Membrane Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Morphogenesis Of An Epithelium
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway	Estrogen-dependent gene expression
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Severe insulin-resistant type 2 diabetes ( 34737425) Uterine fibroids ( 30194396 31649266)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	12 interacting genes: BCAR3 CASP8 CDKN2C ESR1 HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3
Entrez ID		79728	9687
HPRD ID		07966	13611
Ensembl ID		ENSG00000083093	ENSG00000196208
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	Q4ZG55
PDB IDs		2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Regulation Of MiRNA Metabolic Process Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Population Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of MiRNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Signal Transduction Branch Elongation Of An Epithelium Regulation Of Fibroblast Proliferation Hyaluronan Catabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Differentiation Regulation Of MAPK Cascade Response To Estradiol Positive Regulation Of Cell Communication Positive Regulation Of Signaling Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Population Proliferation Developmental Growth Branching Morphogenesis Of An Epithelial Tube Uterus Development Glycosaminoglycan Catabolic Process Regulation Of Extracellular Matrix Assembly Hyaluronan Metabolic Process Regulation Of Macrophage Differentiation Morphogenesis Of A Branching Epithelium Negative Regulation Of MiRNA Transcription Positive Regulation Of Extracellular Matrix Organization Animal Organ Development Morphogenesis Of A Branching Structure Negative Regulation Of Cell Growth Positive Regulation Of MAPK Cascade Apoptotic Process Anatomical Structure Morphogenesis Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Endoderm Development Positive Regulation Of Cell Population Proliferation Protein-membrane Adaptor Activity Programmed Cell Death Cell Death Response To Stress
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