PALB2 and RAD51AP1

Number of citations of the paper that reports this interaction (PubMedID 20871616)
24

Data Source:
BioGRID (pull down)

		PALB2	RAD51AP1
Description		partner and localizer of BRCA2	RAD51 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding	DNA Secondary Structure Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding D-loop DNA Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Reciprocal Meiotic Recombination Interstrand Cross-link Repair Meiotic Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	10 interacting genes: APP ATRX DMC1 LRRK2 MAP3K1 NEDD4 NUCKS1 PALB2 RAD51 SIAH1
Entrez ID		79728	10635
HPRD ID		07966	04350
Ensembl ID		ENSG00000083093	ENSG00000111247
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	B4DUS5 F5H1Y0 Q96B01
PDB IDs		2W18 3EU7 7S4A 8YAP
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Recombinational Repair Double-strand Break Repair Via Homologous Recombination Homologous Recombination DNA Strand Exchange Activity Replication Fork Processing DNA Damage Response DNA Strand Invasion DNA Recombinase Assembly Chromosome Organization Involved In Meiotic Cell Cycle Anatomical Structure Morphogenesis DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To Manganese Ion Cellular Response To Stress Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Macromolecule Metabolic Process Response To Hydroxyurea Response To Manganese Ion Lateral Element Single-stranded DNA Binding Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus DNA Metabolic Process ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Response To Catecholamine Double-stranded DNA Binding Reproductive Process Perikaryon MAP Kinase Kinase Kinase Activity Response To Stress Regulation Of Membrane Potential Response To Radiation Response To X-ray Reciprocal Meiotic Recombination Calcium-mediated Signaling Amyloid Fibril Formation Cellular Response To Radiation Chromatin Binding Nuclear Chromosome Chromosome, Telomeric Region Male Gamete Generation Spermatogenesis ATP-dependent Activity, Acting On DNA Regulation Of Intrinsic Apoptotic Signaling Pathway Protein-DNA Complex Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Gamete Generation
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