PALB2 and RAD51AP1

Number of citations of the paper that reports this interaction (PMID 20871616)
19

Data Source:
BioGRID (pull down)

		PALB2	RAD51AP1
Gene Name		partner and localizer of BRCA2	RAD51 associated protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus
	Molecular Function	DNA Binding Protein Binding	Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair Mesoderm Development Organ Morphogenesis Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process	Double-strand Break Repair Via Homologous Recombination DNA Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Cellular Response To Ionizing Radiation
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Colorectal cancer ( 23263487) Phosphorus levels ( 20558539)
Protein-Protein Interactions		3 interactors: BRCA2 HNRNPC RAD51AP1	5 interactors: APP NEDD4 PALB2 RAD51 SIAH1
Entrez ID		79728	10635
HPRD ID		07966	04350
Ensembl ID		ENSG00000083093	ENSG00000111247
Uniprot IDs		Q86YC2	B4DUS5 Q96B01
PDB IDs		2W18 3EU7
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair DNA Recombination Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Response To Radiation 3'-UTR-mediated MRNA Stabilization Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Modification Regulation Of Mammary Gland Epithelial Cell Proliferation Chromatin Organization Inner Cell Mass Cell Proliferation Oocyte Maturation MRNA Stabilization Regulation Of Double-strand Break Repair Blastocyst Growth Cellular Response To DNA Damage Stimulus Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Chromosome Organization Histone H3 Acetylation Oocyte Development DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Histone H4 Acetylation Response To Gamma Radiation Regulation Of MRNA Stability Regulation Of RNA Stability Centrosome Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cytokinesis Cellular Response To Ionizing Radiation Male Meiosis Regulation Of DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination ATP-dependent Chromatin Remodeling Cell Aging	Neuromuscular Junction Development Neuron Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Radiation Neuron Death Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Synapse Structure Or Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Response To Radiation Double-strand Break Repair Neuron Projection Development Synaptic Growth At Neuromuscular Junction Anatomical Structure Morphogenesis Synapse Organization Collateral Sprouting In Absence Of Injury Positive Regulation Of DNA Ligation Cellular Response To Camptothecin Neuron Development Intracellular Receptor Signaling Pathway Reproduction Response To Camptothecin Response To Abiotic Stimulus DNA Recombination Collateral Sprouting Axon Midline Choice Point Recognition DNA Recombinase Assembly Neuron Differentiation Cell Projection Organization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Progesterone Receptor Signaling Pathway Axon Choice Point Recognition Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Locomotion Developmental Growth Glucocorticoid Receptor Signaling Pathway Neuron Remodeling Response To Light Stimulus Response To Stress Cellular Response To Stress Protein Targeting To Lysosome Generation Of Neurons Axon Guidance Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway DNA Unwinding Involved In DNA Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Lysosome
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	atm atr brca1 coactivator collectively depleted directed encode endocrine familial homologous joining lineage lost melanocytes melanoma melanomas men1 methyltransferase neoplasia nonhomologous oncogene promoters raising recombination stimulating suppressor trimethylation
Tagcloud (Difference) ?		alleles brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	atr coactivator collectively depleted directed encode endocrine familial homologous joining lineage lost melanocytes melanoma melanomas men1 methyltransferase neoplasia nonhomologous oncogene promoters raising recombination stimulating suppressor trimethylation
Tagcloud (Intersection) ?		atm brca1