BRCA2 and SERPINH1

Number of citations of the paper that reports this interaction (PMID 19578754)
0

Data Source:
BioGRID (pull down)

		BRCA2	SERPINH1
Gene Name		breast cancer 2, early onset	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding	Serine-type Endopeptidase Inhibitor Activity Collagen Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation
Pathways		Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange	Collagen formation Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733)	Height ( 20881960 22021425)
Protein-Protein Interactions		34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11	17 interactors: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 HIST1H1B HMP19 KLF13 PPARG SLC2A4 SLC35F6 UBQLN4 UBTF
Entrez ID		675	871
HPRD ID		02554	02968
Ensembl ID		ENSG00000139618	ENSG00000149257
Uniprot IDs		P51587	A8K259 P50454
PDB IDs		1N0W 3EU7
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process	Negative Regulation Of DNA Replication DNA-templated Transcription, Initiation Regulation Of Cell Proliferation Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Proliferation Regulation Of DNA Replication Cell Maturation Regulation Of Cellular Component Organization Transcription Initiation From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Cellular Metabolic Process Brown Fat Cell Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Metformin Low-density Lipoprotein Particle Receptor Biosynthetic Process Negative Regulation Of Pancreatic Stellate Cell Proliferation Replication Fork Arrest Response To Diuretic Amylopectin Biosynthetic Process Single Organism Reproductive Process Regulation Of Cellular Process Chromatin Organization Regulation Of Cholesterol Transporter Activity Cellular Response To Vitamin E DNA-templated Transcription, Elongation Reproductive Process Apoptotic Signaling Pathway Regulation Of Cell Growth Brain Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Protein Stabilization Macromolecule Biosynthetic Process Head Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Multicellular Organism Reproduction Steroid Hormone Mediated Signaling Pathway Meiosis I Membrane Organization DNA-dependent DNA Replication Cellular Response To Oxygen Levels Transcription From RNA Polymerase II Promoter Female Gonad Development Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Development Of Primary Female Sexual Characteristics Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation
Tagcloud ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	act biochemical bones caused chaperones consequences deficiency destabilization disorder dominant encode fkbp10 forms genes genetic growing include interact little maturation mislocalization moderately mutant mutation posttranslational predominantly produce reveal secondarily severe
Tagcloud (Difference) ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	act biochemical bones caused chaperones consequences deficiency destabilization disorder dominant encode fkbp10 forms genes genetic growing include interact little maturation mislocalization moderately mutant mutation posttranslational predominantly produce reveal secondarily severe
Tagcloud (Intersection) ?