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BRCA2 and MAGED1
Number of citations of the paper that reports this interaction (PubMedID
15930293
)
42
Data Source:
BioGRID
(two hybrid)
BRCA2
MAGED1
Description
BRCA2 DNA repair associated
MAGE family member D1
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Secretory Granule
Protein-containing Complex
BRCA2-MAGE-D1 Complex
DNA Repair Complex
Chromatin
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Protein-containing Complex
Molecular Function
Protease Binding
DNA Binding
Single-stranded DNA Binding
Histone Acetyltransferase Activity
Protein Binding
Histone H3 Acetyltransferase Activity
Histone H4 Acetyltransferase Activity
Identical Protein Binding
Gamma-tubulin Binding
Transcription Coactivator Activity
Protein Binding
Identical Protein Binding
Biological Process
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
Oocyte Maturation
Inner Cell Mass Cell Proliferation
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair
DNA Recombination
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Male Meiosis I
Spermatogenesis
Brain Development
Cell Population Proliferation
Female Gonad Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To X-ray
Response To UV-C
Response To Gamma Radiation
Hemopoiesis
DNA Damage Response, Signal Transduction By P53 Class Mediator
Replication Fork Processing
Regulation Of Cytokinesis
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Chordate Embryonic Development
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Mitotic Cell Cycle
Chromosome Organization
Centrosome Duplication
Establishment Of Protein Localization To Telomere
Hematopoietic Stem Cell Proliferation
Cellular Response To Ionizing Radiation
Stem Cell Proliferation
Cellular Senescence
Mitotic Recombination-dependent Replication Fork Processing
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Circadian Regulation Of Gene Expression
Protein Localization To Nucleus
Regulation Of Circadian Rhythm
Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Rhythmic Process
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
HDR through MMEJ (alt-NHEJ)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 translocation to the nucleus
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Impaired BRCA2 binding to SEM1 (DSS1)
NRAGE signals death through JNK
Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
Ovarian cancer
Fanconi anemia
Breast cancer
Pancreatic cancer
GWAS
Apolipoprotein B levels (
32203549
)
Basal cell carcinoma (
31174203
)
Breast cancer (
23535733
23535729
29059683
)
Cancer (
27197191
)
Cancer (pleiotropy) (
27197191
)
Cutaneous squamous cell carcinoma (
32041948
)
Keratinocyte cancer (MTAG) (
31174203
)
LDL cholesterol (
24097068
)
LDL cholesterol levels (
32203549
28334899
)
Lung cancer (
28604730
24880342
)
Lung cancer in ever smokers (
28604730
)
Small cell lung carcinoma (
28604730
)
Squamous cell carcinoma (
31174203
)
Squamous cell lung carcinoma (
28604730
)
Bell's palsy (
33602968
)
Interacting Genes
47 interacting genes:
ATR
BCCIP
BRCA1
BUB1B
CCNA1
CCNA2
CCND1
CCNE1
CDK1
CDK2
CFAP52
CHEK1
CHEK2
DMC1
DYNC1LI1
DYNC1LI2
EMSY
ERCC5
FANCD2
FANCE
FANCG
FANCI
FLNA
H2AX
HMG20B
HNRNPC
KAT2B
LIMD1
MAGED1
PALB2
PDS5B
PLEC
PLK1
RAD51
RNASEH2A
RPA1
SEM1
SERPINH1
SMAD3
STAT5A
TP53
TP53BP1
UQCC1
USP11
USP21
WTIP
XPO1
128 interacting genes:
AGRN
AKAP9
ARHGEF16
ARID5A
ARNT2
BAG3
BAG4
BARD1
BHLHE40
BIRC8
BRCA2
C1orf94
CA8
CAPN7
CCDC120
CCDC33
CDC23
CERCAM
CFAP206
CHERP
DAB1
DAZAP2
DDX6
DLX4
DLX5
DMRT2
EIF3J
EIF4E2
EP300
ERCC3
FAM83A
FOXD2
FOXH1
FOXI1
FXR1
FXR2
GATA5
GLRA1
GLYCTK
GPANK1
GPR135
GRAP2
HEMK1
HGS
HIVEP1
HNRNPH1
HNRNPLL
HOXC9
HSF2BP
HUNK
KPNA2
KPNA6
KRTAP19-5
KRTAP6-1
KRTAP6-3
LARP4B
LENG8
LONRF1
MAPK1IP1L
MAPK3
MDFI
MEOX2
MGAT5B
MKRN3
MPC1
MSX2
NAF1
NGFR
NOTCH1
NOTO
NPAS4
NUMBL
PHF1
PITX1
PJA1
PJA2
PLK1
PNMA5
POM121
PRKAB2
PROP1
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR35
PSMF1
RAMAC
RBFOX1
RBFOX2
RBM23
RBPMS
RBPMS2
RFX1
RHOXF2
RNF6
RNF8
ROR2
RUSC1
RXFP4
SIM2
SIRT7
SMAP2
SMN1
SMN2
SNRPC
SOX10
SOX5
TBX6
TFG
TIAL1
TLX3
TRAF4
TRIM28
TSGA10IP
TTC23
TTC32
TUBA4A
UNC5A
VASP
VENTX
XIAP
YTHDF1
ZFYVE26
ZIC1
ZNF488
ZNF688
Entrez ID
675
9500
HPRD ID
02554
02202
Ensembl ID
ENSG00000139618
ENSG00000179222
Uniprot IDs
A0A7P0T9D7
A0A8V8TPZ2
P51587
Q9Y5V3
PDB IDs
1N0W
3EU7
6GY2
6HQU
7BDX
7LDG
8BR9
8C3J
8C3N
8PBC
8PBD
8QQE
8R2G
8UVW
Enriched GO Terms of Interacting Partners
?
DNA Repair
DNA Metabolic Process
DNA Damage Response
DNA Damage Checkpoint Signaling
Cellular Response To Stress
Double-strand Break Repair
Nucleoplasm
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Mitotic DNA Damage Checkpoint Signaling
Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Mitotic DNA Integrity Checkpoint Signaling
Negative Regulation Of Cell Cycle
Cell Cycle Phase Transition
Nucleus
Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Chromosome, Telomeric Region
Regulation Of Mitotic Cell Cycle
Protein Localization To Site Of Double-strand Break
G2/M Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
Chromosome Organization
Recombinational Repair
Response To Ionizing Radiation
Cell Cycle G2/M Phase Transition
Chromosome
DNA Repair Complex
Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Organelle Organization
Regulation Of Cell Cycle G2/M Phase Transition
Interstrand Cross-link Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Condensed Nuclear Chromosome
Centrosome
DNA Recombination
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Localization To Chromosome
Regulation Of Chromosome Organization
Cyclin A2-CDK2 Complex
Response To Radiation
Damaged DNA Binding
Regulation Of RNA Metabolic Process
Cytoplasmic Stress Granule
Sequence-specific Double-stranded DNA Binding
Chromatin
Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Binding
Regulation Of Primary Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Gene Expression
DNA Binding
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
System Development
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Macromolecule Metabolic Process
Nucleic Acid Binding
Nervous System Development
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Biosynthetic Process
Regulation Of MRNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Pattern Specification Process
Embryonic Morphogenesis
MRNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Identical Protein Binding
Negative Regulation Of RNA Metabolic Process
Cytoplasmic Ribonucleoprotein Granule
Nuclear Androgen Receptor Binding
RNA Binding
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
Positive Regulation Of Protein Localization To Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Nucleocytoplasmic Transport
Viral Penetration Into Host Nucleus
Regulation Of RNA Splicing
Transcription Regulator Complex
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