BRCA2 and CCNA2

Number of citations of the paper that reports this interaction (PMID 15800615)
100

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		BRCA2	CCNA2
Gene Name		breast cancer 2, early onset	cyclin A2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex	Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding	Protein Binding Protein Kinase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Ras Protein Signal Transduction Regulation Of G2/M Transition Of Mitotic Cell Cycle Organ Regeneration Response To Estradiol Response To Glucagon Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Cell Division
Pathways		Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange	Cellular Senescence G2/M Transition Orc1 removal from chromatin Cyclin E associated events during G1/S transition Cyclin A/B1 associated events during G2/M transition G1/S Transition G2 Phase Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase S Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Orc1 removal from chromatin SCF(Skp2)-mediated degradation of p27/p21 Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G2-G2/M phases
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733)
Protein-Protein Interactions		34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11	50 interactors: ARID4A BRCA1 BRCA2 BTG1 CALM1 CDC20 CDC25C CDC27 CDC6 CDK1 CDK2 CDK3 CDK7 CDKN1A CDKN1B CDT1 CKS1B CKS1BP7 CKS2 DTNBP1 E2F1 E2F3 FEN1 FZR1 HERC5 HIRA HIST1H1A HIST1H1B ITGB3BP KAT2B MYBL2 NFYA PGR POLA1 PRC1 PSMD4 PTMA RAD23A RB1 RBL1 RBL2 RPA1 SKP1 SKP2 SP1 TAF1 TP53 TRAF3IP1 UBTF USP37
Entrez ID		675	890
HPRD ID		02554	00453
Ensembl ID		ENSG00000139618	ENSG00000145386
Uniprot IDs		P51587	P20248
PDB IDs		1N0W 3EU7	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process	Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Organelle Organization Cell Cycle Checkpoint Cell Division Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Chromosome Organization Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Chromatin Organization Regulation Of Protein Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Mitotic Nuclear Division Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Positive Regulation Of Gene Expression Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Proteasomal Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Chromatin Modification DNA Replication Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Heterocycle Metabolic Process
Tagcloud ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	calm3 cblb ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?