BRCA2 and FANCE

Number of citations of the paper that reports this interaction (PMID 15199141)
81

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		BRCA2	FANCE
Gene Name		breast cancer 2, early onset	Fanconi anemia, complementation group E
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Secretory Granule BRCA2-MAGE-D1 Complex Protein Complex	Nucleus Nucleoplasm Fanconi Anaemia Nuclear Complex
	Molecular Function	Protease Binding Single-stranded DNA Binding Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity H4 Histone Acetyltransferase Activity Gamma-tubulin Binding	Molecular_function
	Biological Process	Double-strand Break Repair Via Homologous Recombination Cytokinesis Oocyte Maturation Inner Cell Mass Cell Proliferation DNA Repair Nucleotide-excision Repair Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Male Meiosis I Spermatogenesis Brain Development Cell Aging Female Gonad Development Response To X-ray Response To UV-C Response To Gamma Radiation Hemopoiesis Regulation Of Cytokinesis Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Replication Fork Protection Centrosome Duplication	DNA Repair
Pathways		Homologous DNA pairing and strand exchange Meiotic recombination Fanconi Anemia pathway Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Presynaptic phase of homologous DNA pairing and strand exchange	Fanconi Anemia pathway
Drugs
Diseases
GWAS		Breast cancer ( 23535729 23535733)	Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		34 interactors: ATM ATR BCCIP BRCA1 BUB1B C11orf30 CCNA2 CCNE1 CDK1 CDK2 CFAP52 CHEK2 DMC1 FANCD2 FANCE FANCG FLNA H2AFX HMG20B HNRNPC KAT2B MAGED1 NEDD4 PALB2 PLK1 RAD51 RPA1 SERPINH1 SHFM1 SMAD3 STAT5A TP53 UQCC1 USP11	8 interactors: BRCA2 CHEK1 FANCA FANCC FANCD2 FANCF FANCG HES1
Entrez ID		675	2178
HPRD ID		02554	02943
Ensembl ID		ENSG00000139618	ENSG00000112039
Uniprot IDs		P51587	Q9HB96
PDB IDs		1N0W 3EU7	2ILR
Enriched GO Terms of Interacting Partners?		Cell Cycle Cellular Response To DNA Damage Stimulus Cell Cycle Process DNA Repair DNA Metabolic Process Cell Cycle Checkpoint Cellular Response To Stress Regulation Of Protein Metabolic Process DNA Damage Checkpoint Double-strand Break Repair Response To Stress Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle DNA Recombination Chromosome Organization Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Response To Stimulus Meiotic Cell Cycle Replicative Senescence Mitotic Cell Cycle Process G2 DNA Damage Checkpoint Cellular Response To Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Meiotic Nuclear Division Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Response To Gamma Radiation Response To Abiotic Stimulus Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Cell Aging Reproduction DNA Replication Cellular Metabolic Process	DNA Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Single Organism Reproductive Process Reproductive Process Developmental Process Involved In Reproduction Female Gonad Development Cellular Response To Stress Development Of Primary Female Sexual Characteristics Reproduction Reproductive Structure Development Reproductive System Development Gonad Development Development Of Primary Sexual Characteristics Gamete Generation Sex Differentiation Nucleobase-containing Compound Metabolic Process Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Radiation Nitrogen Compound Metabolic Process Response To Stress Meiotic Nuclear Division Cell Cycle Meiotic Cell Cycle Cellular Response To Stimulus Germ Cell Development Response To Gamma Radiation Male Meiosis Response To Stimulus Cell Cycle Process Developmental Process Ovarian Follicle Development Cell Aging Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Nucleotide-excision Repair Negative Regulation Of DNA Metabolic Process Ovulation Cycle Process Spermatogenesis Male Gamete Generation Meiosis I
Tagcloud ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	chek2 clk2 comprehensively escc esophageal fen1 gc genetics genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Difference) ?		185delag 5677insa adriamycin brca1 breaks camptothecin cip1 clones confer doubling du germ insbrca1 mdm obvious parental probands prostate slightly stably strand susceptibility taxol transfected transgenes vector virtue waf1 wtbrca1	chek2 clk2 comprehensively escc esophageal fen1 gc genetics genotyped germline gtf2h3 han hel308 linxian mpg mre11a pole polq propensity rad54b rad54l resampling shanxi smug1 snps sum tdg validate warranted
Tagcloud (Intersection) ?