PALB2 and RAD51C

Number of citations of the paper that reports this interaction (PubMedID 24141787)
56

Data Source:
BioGRID (pull down)

		PALB2	RAD51C
Description		partner and localizer of BRCA2	RAD51 paralog C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Cell Junction Rad51B-Rad51C-Rad51D-XRCC2 Complex Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Protein Binding	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding Crossover Junction DNA Endonuclease Activity ATP-dependent DNA Damage Sensor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Meiotic DNA Recombinase Assembly Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Sister Chromatid Cohesion Female Meiosis Sister Chromatid Cohesion Reciprocal Meiotic Recombination Male Meiosis I Spermatogenesis Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Cognitive function ( 25644384) Primary tooth development (time to first tooth eruption) ( 23704328) Testicular germ cell tumor ( 23666239 23666240)
Interacting Genes		31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3	8 interacting genes: APP PALB2 RAD51 RAD51B RAD51D SPG21 SWSAP1 XRCC3
Entrez ID		79728	5889
HPRD ID		07966	04143
Ensembl ID		ENSG00000083093	ENSG00000108384
Uniprot IDs		A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2	A0A8V8TML8 O43502
PDB IDs		2W18 3EU7 7S4A 8YAP	8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I	Recombinational Repair Double-strand Break Repair Via Homologous Recombination ATP-dependent DNA Damage Sensor Activity Double-strand Break Repair DNA Recombination Telomere Maintenance Via Recombination DNA Repair Four-way Junction DNA Binding Mitotic Recombination Single-stranded DNA Binding Reciprocal Meiotic Recombination Replication Fork DNA Binding DNA Metabolic Process ATP-dependent Activity, Acting On DNA Developmental Growth DNA Damage Response Homologous Recombination Interstrand Cross-link Repair Rad51B-Rad51C-Rad51D-XRCC2 Complex DNA Strand Invasion Regulation Of Cell Cycle Nucleic Acid Metabolic Process Response To Stress Macromolecule Metabolic Process Telomere Maintenance Collateral Sprouting Telomere Organization Cellular Response To Stress Nucleobase-containing Compound Metabolic Process Cell Maturation Chromosome, Telomeric Region Neuron Maturation Developmental Maturation In Utero Embryonic Development Chordate Embryonic Development Reproductive Process Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Response To Gamma Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation
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