BEND5 and USP7

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		BEND5	USP7
Gene Name		BEN domain containing 5	ubiquitin specific peptidase 7 (herpes virus-associated)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus	Nucleus Cytosol PML Body
	Molecular Function		P53 Binding Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding
	Biological Process		Transcription-coupled Nucleotide-excision Repair Multicellular Organismal Development Maintenance Of DNA Methylation Viral Process Histone Deubiquitination Protein Deubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: APP BUD31 BZRAP1 CTNNBIP1 DDR1 EIF3D FAM161A GFI1B GORASP2 GRAP2 LCE1B PRKAB2 RTP5 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417	85 interactors: ACD ARNT2 ATXN1 BCOR BEND5 BMI1 CBX8 CHEK1 CLSPN CREB3L3 DAXX DNAJA3 DNMT1 DNMT3A EWSR1 EZH2 FAM175B FOXN2 HECW1 HERPUD1 HIST3H2BB HTRA2 KAT5 KLHL8 MAGEE1 MAL MARCH7 MCMBP MDM2 MDM4 MYD88 NECAB2 PCGF2 PEG3 PEPD PHLDB2 PICK1 PJA1 PLA2G2A PLEKHO1 PPARG PPL RADIL RARA RB1 RBCK1 RELA RFFL RING1 RNF2 RNF220 SMAD3 SUMO1 SUZ12 SYVN1 TANK TBCB TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM27 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBC UBE2E1 UBE2S UHRF2 USP15 USP21 USP28 WWP2 XPC ZEB1 ZMYND8 ZNF423
Entrez ID		79656	7874
HPRD ID		07756	03950
Ensembl ID			ENSG00000187555
Uniprot IDs		Q7L4P6	B7Z815 Q6U8A4 Q93009
PDB IDs			1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Protein Deubiquitination Protein Catabolic Process Regulation Of Receptor Activity Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Smooth Muscle Cell-matrix Adhesion Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process Cellular Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Modification By Small Protein Conjugation Protein Ubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Metabolic Process Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Process Modification-dependent Protein Catabolic Process Chromosome Organization Chromatin Organization Regulation Of Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Transcription, DNA-templated Cellular Macromolecule Catabolic Process Apoptotic Process RNA Biosynthetic Process Programmed Cell Death Chromatin Modification Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Signal Transduction Histone Ubiquitination Cell Death
Tagcloud ?		app apps aptamer deliver delivery endothelial entrapped evaporation flurbiprofen functionalized glycol importantly loaded micelles murine offer peg pla polyethylene polylactic quantified retention solvent spectroscopy therapeutically transferrin transferring unmodified w	accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Difference) ?		app apps aptamer deliver delivery endothelial entrapped evaporation flurbiprofen functionalized glycol importantly loaded micelles murine offer peg pla polyethylene polylactic quantified retention solvent spectroscopy therapeutically transferrin transferring unmodified w	accordingly adenocarcinoma bad carcinoma clarified de downregulation excluding h460 hbe indicator invasion invasive mdm2 mesenchymal metastasis nsclc overexpression preliminary regulate serve squamous stabilization tumorous ubiquitination upregulation usp7high usp7low vshrna
Tagcloud (Intersection) ?