BEND5 and PTGR2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BEND5	PTGR2
Name		BEN domain containing 5	prostaglandin reductase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus	Cytoplasm
	Molecular Function	DNA Binding Protein Binding	Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor 15-oxoprostaglandin 13-reductase [NAD(P)+] Activity
	Biological Process	Negative Regulation Of DNA-templated Transcription	Lipid Metabolic Process Prostaglandin Metabolic Process
Pathways		None	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		None	Indomethacin (5E,13E)-11-HYDROXY-9,15-DIOXOPROSTA-5,13-DIEN-1-OIC ACID
GWAS		No GWAS studies recorded	Birth weight ( 31043758 ) Mean corpuscular volume ( 27863252 ) Rosacea symptom severity ( 29771307 ) Serum uric acid levels ( 29559957 )
Interacting Genes		31 interacting genes: APP BUD31 CFTR CTNNBIP1 DDR1 EIF3D ERBB3 FAM161A FXR1 GFI1B GORASP2 GRAP2 HOXA1 LCE1B LMO3 NTAQ1 PIMREG PRKAB2 PTGR2 RTP5 SMARCD1 TSC1 TSPOAP1 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417 ZNF688	1 interacting genes: BEND5
Entrez ID		79656	145482
HPRD ID		07756	09782
Ensembl ID		ENSG00000162373	ENSG00000140043
Uniprot IDs		A0A0S2Z5N0 Q7L4P6	G3V2R9 Q8N8N7 V9HW32
PDB IDs		Not available	2VNA 2W4Q 2W98 2ZB4 2ZB7 2ZB8
GO Terms Enriched among Interactors		Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Long-term Synaptic Potentiation Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Signaling Receptor Activity	None