CTSB and CST3

Number of citations of the paper that reports this interaction (PMID 1996959)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CTSB	CST3
Gene Name		cathepsin B	cystatin C
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleolus Mitochondrion Lysosome Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding	Beta-amyloid Binding Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Innate Immune Response Decidualization Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Defense Response Negative Regulation Of Peptidase Activity Negative Regulation Of Collagen Catabolic Process Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Regulation Of Tissue Remodeling Extracellular Fibril Organization Negative Regulation Of Proteolysis Negative Regulation Of Elastin Catabolic Process Negative Regulation Of Blood Vessel Remodeling
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation Collagen degradation MHC class II antigen presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System	Amyloids
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS			Chronic kidney disease ( 20383146) Cystatin C ( 17903292)
Protein-Protein Interactions		33 interactors: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD IGF1 INS MARCKS PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 UBQLN4 XRN1	9 interactors: ATXN1 C4A CSTB CTSB CTSD CTSL CTSS PDZD2 RNF115
Entrez ID		1508	1471
HPRD ID		00287	05056
Ensembl ID		ENSG00000164733	ENSG00000101439
Uniprot IDs		P07858	P01034
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH	1G96 1R4C 1TIJ 3GAX 3NX0 3PS8 3QRD 3S67 3SVA
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Binding Regulation Of Growth Regulation Of Cellular Process Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Binding Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Coagulation Positive Regulation Of Cell Cycle Developmental Process Negative Regulation Of Wound Healing Organ Development Negative Regulation Of MAPK Cascade Response To Abiotic Stimulus Regulation Of Protein Import Into Nucleus Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus	Cellular Response To Thyroid Hormone Stimulus Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Response To Thyroid Hormone Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Extracellular Matrix Organization Extracellular Structure Organization Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Positive Regulation Of Innate Immune Response Protein Catabolic Process Positive Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Regulation Of Innate Immune Response Proteolysis Adaptive Immune Response Antigen Processing And Presentation Innate Immune Response Cellular Macromolecule Catabolic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Immune System Process Immune Response-regulating Signaling Pathway Basement Membrane Disassembly Macrophage Apoptotic Process Adult Locomotory Behavior Immune Response Regulation Of Immune System Process Defense Response Cellular Response To Hormone Stimulus Adult Behavior Myeloid Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Inflammatory Cell Apoptotic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Locomotory Behavior Regulation Of Apoptotic Cell Clearance Negative Regulation Of Endopeptidase Activity Response To Hormone Negative Regulation Of Peptidase Activity
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	airflow analysing antiprotease bronchial brushings categorical causal causality cd22 copd curation cystatin dataset datasets eqtl fev fvc genomics integrative manual modelling oxidant relations silico snps trait triplets upregulating xenobiotic
Tagcloud (Intersection) ?