CTSB and S100A10

Number of citations of the paper that reports this interaction (PMID 10777578)
27

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		CTSB	S100A10
Gene Name		cathepsin B	S100 calcium binding protein A10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleolus Mitochondrion Lysosome Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extrinsic Component Of Plasma Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding	Calcium Ion Binding Protein Binding Lipid Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Innate Immune Response Decidualization Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Membrane Raft Assembly Membrane Budding Positive Regulation Of Rac GTPase Activity Positive Regulation Of Binding Protein Heterotetramerization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation Collagen degradation MHC class II antigen presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System	Dissolution of Fibrin Clot Orphan transporters
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS
Protein-Protein Interactions		33 interactors: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD IGF1 INS MARCKS PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 UBQLN4 XRN1	13 interactors: ANXA2 ANXA7 BAD CDK16 COPS6 CTSB FSHR KCNK3 PLA2G4C PLG SETDB1 TRPV5 TRPV6
Entrez ID		1508	6281
HPRD ID		00287	00232
Ensembl ID		ENSG00000164733	ENSG00000197747
Uniprot IDs		P07858	P60903
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH	1A4P 1BT6 4DRW 4FTG 4HRE 4HRG 4HRH
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Binding Regulation Of Growth Regulation Of Cellular Process Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Binding Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Coagulation Positive Regulation Of Cell Cycle Developmental Process Negative Regulation Of Wound Healing Organ Development Negative Regulation Of MAPK Cascade Response To Abiotic Stimulus Regulation Of Protein Import Into Nucleus Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus	Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Cellular Homeostasis Reproductive Process Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Calcium Ion Homeostasis Homeostatic Process Calcium Ion Homeostasis Cellular Response To Chromate Response To Metal Ion Extracellular Matrix Organization Extracellular Structure Organization Chemical Homeostasis Regulation Of Blood Coagulation Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Extracellular Matrix Disassembly Cellular Metal Ion Homeostasis Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Anatomical Structure Development Protein Tetramerization Cellular Cation Homeostasis Mononuclear Cell Migration Cellular Response To Oxygen Levels Cellular Ion Homeostasis Response To Calcium Ion Catabolic Process Metal Ion Homeostasis Regulation Of Wound Healing Response To Inorganic Substance Reproductive Structure Development Reproductive System Development Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process Positive Regulation Of Fibrinolysis Cellular Response To Inorganic Substance Positive Regulation Of Type B Pancreatic Cell Development Follicle-stimulating Hormone Signaling Pathway Cellular Chemical Homeostasis Single Organism Reproductive Process Establishment Of Localization In Cell Organ Development System Development Developmental Process Ion Homeostasis Positive Regulation Of Glucokinase Activity
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	annexin authentic baculovirus biochemical contained cytoskeleton derivatives display endocytic ii incorporation interference intestine lies mediating member mutants p11 porcine purified residue residues secretory ser serine spatial subjected substitutions
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	annexin authentic baculovirus biochemical contained cytoskeleton derivatives display endocytic ii incorporation interference intestine lies mediating member mutants p11 porcine purified residue residues secretory ser serine spatial subjected substitutions
Tagcloud (Intersection) ?