CTSB and BGLAP

Number of citations of the paper that reports this interaction (PubMedID 9076588)
0

Data Source:
HPRD (in vivo)

		CTSB	BGLAP
Description		cathepsin B	bone gamma-carboxyglutamate protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Dendrite Vesicle Cell Projection Perikaryon
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding	Hormone Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Bone Hydroxyapatite Binding Metal Ion Binding
	Biological Process	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Skeletal System Development Ossification Osteoblast Differentiation Positive Regulation Of Neurotransmitter Secretion Cell Adhesion Signal Transduction Brain Development Learning Or Memory Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Gravity Response To Zinc Ion Response To Activity Bone Mineralization Regulation Of Bone Mineralization Biomineral Tissue Development Response To Nutrient Levels Response To Vitamin K Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin D Response To Testosterone Response To Hydroxyisoflavone Cellular Response To Zinc Ion Starvation Response To Macrophage Colony-stimulating Factor Glucose Homeostasis Response To Estrogen Type B Pancreatic Cell Proliferation Regulation Of Bone Resorption Response To Ethanol Regulation Of Osteoclast Differentiation System Development Stem Cell Differentiation Cognition Response To Glucocorticoid Bone Development Cellular Response To Vitamin D Cellular Response To Growth Factor Stimulus Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Bone Development Regulation Of Testosterone Biosynthetic Process
Pathways		Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1	Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins RUNX2 regulates osteoblast differentiation
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE	Menadione Phylloquinone gamma-carboxy-L-glutamic acid Gallium nitrate
Diseases		Tropical calcific pancreatitis
GWAS		A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Estimated glomerular filtration rate ( 30604766) Mean corpuscular hemoglobin concentration ( 20139978) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) White matter hyperintensity burden ( 25663218)
Interacting Genes		40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1	6 interacting genes: ASPH CTSB CTSD CTSH CTSS GGCX
Entrez ID		1508	632
HPRD ID		00287	00205
Ensembl ID		ENSG00000164733	ENSG00000242252
Uniprot IDs		A0A024R374 P07858	P02818
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN	8XS1 9BUR 9BUX
Enriched GO Terms of Interacting Partners?		Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding	Cysteine-type Endopeptidase Activity Cellular Response To Thyroid Hormone Stimulus Ficolin-1-rich Granule Lumen Response To Thyroid Hormone Tertiary Granule Lumen Endolysosome Lumen Endopeptidase Activity Antigen Processing And Presentation Extracellular Matrix Peptidase Activity Proteoglycan Binding Lysosome Cysteine-type Peptidase Activity Positive Regulation Of Cation Channel Activity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Collagen Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Protein Maturation Cellular Response To Hormone Stimulus Collagen Metabolic Process Collagen Binding Antigen Processing And Presentation Of Peptide Antigen Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity HLA-A Specific Activating MHC Class I Receptor Activity Gamma-glutamyl Carboxylase Activity Lysosomal Lumen Melanosome Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Extracellular Space Aspartic-type Peptidase Activity Kininogen Binding Vitamin Binding Negative Regulation Of Bone Development Positive Regulation Of Monoatomic Ion Transmembrane Transport Protein Metabolic Process Response To Hormone Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Hydrolase Activity Response To Odorant Dichotomous Subdivision Of Terminal Units Involved In Lung Branching Basement Membrane Disassembly Negative Regulation Of Testosterone Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?