CTSB and SRPX2

Number of citations of the paper that reports this interaction (PMID 18718938)
10

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		CTSB	SRPX2
Gene Name		cathepsin B	sushi-repeat containing protein, X-linked 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Intracellular Nucleolus Mitochondrion Lysosome Endolysosome Lumen Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Cell Surface Cell Junction Excitatory Synapse Synaptic Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Proteoglycan Binding	Receptor Binding Protein Binding Hepatocyte Growth Factor Binding Identical Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Innate Immune Response Decidualization Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Angiogenesis Single Organismal Cell-cell Adhesion Regulation Of Phosphorylation Cell Motility Positive Regulation Of Synapse Assembly Vocalization Behavior Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen formation Collagen degradation MHC class II antigen presentation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Adaptive Immune System Innate Immune System
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic Acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}- N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases
GWAS
Protein-Protein Interactions		33 interactors: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD FAM118B HNRNPD IGF1 INS MARCKS PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 UBQLN4 XRN1	3 interactors: ADAMTS4 CTSB PLAUR
Entrez ID		1508	27286
HPRD ID		00287	06726
Ensembl ID		ENSG00000164733	ENSG00000102359
Uniprot IDs		P07858	O60687
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Catalytic Activity Regulation Of Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Positive Regulation Of Fibroblast Proliferation Regulation Of Binding Regulation Of Growth Regulation Of Cellular Process Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Protein Localization To Nucleus Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Binding Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Coagulation Positive Regulation Of Cell Cycle Developmental Process Negative Regulation Of Wound Healing Organ Development Negative Regulation Of MAPK Cascade Response To Abiotic Stimulus Regulation Of Protein Import Into Nucleus Regulation Of Signaling Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus	Extracellular Matrix Disassembly Urokinase Plasminogen Activator Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Attachment Of GPI Anchor To Protein Response To Thyroid Hormone Decidualization Response To Stress C-terminal Protein Lipidation Fibrinolysis Maternal Placenta Development
Tagcloud ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28
Tagcloud (Difference) ?		bag1 bcl2l2 bctis ccna2 comprehend deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2	agenesis anteriorly arx callosum dcx encompass encompasses filamin flna fronto genitalia gpr56 heterotopia lch lcha lchb lchd lissencephaly malformative mcd pachygyria perisylvian periventricular pnh polymicrogyria reln sbh tuba1a xq28
Tagcloud (Intersection) ?