CTSB and IGF1

Number of citations of the paper that reports this interaction (PubMedID 16051222)
0

Data Source:
HPRD (in vitro, in vivo)

		CTSB	IGF1
Description		cathepsin B	insulin like growth factor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Insulin-like Growth Factor Binding Protein Complex Secretory Granule Platelet Alpha Granule Lumen Alphav-beta3 Integrin-IGF-1-IGF1R Complex Insulin-like Growth Factor Ternary Complex Exocytic Vesicle Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding	Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Integrin Binding Hormone Activity Protein Binding Growth Factor Activity Protein Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Skeletal System Development Osteoblast Differentiation Cell Activation Epithelial To Mesenchymal Transition Blood Vessel Remodeling Signal Transduction Ras Protein Signal Transduction Nervous System Development Muscle Organ Development Circadian Rhythm Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Heat Glycolate Metabolic Process Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Muscle Hypertrophy Myotube Differentiation Myotube Cell Development Positive Regulation Of Smooth Muscle Cell Migration Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Proteoglycan Biosynthetic Process Lung Development Positive Regulation Of Cell Migration Androgen Receptor Signaling Pathway Mammary Gland Development Exocrine Pancreas Development Positive Regulation Of Myelination Activation Of Protein Kinase B Activity Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Smooth Muscle Cell Apoptotic Process Multicellular Organism Growth Bone Mineralization Involved In Bone Maturation Wound Healing Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Regulation Of Nitric Oxide Biosynthetic Process Myoblast Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Positive Regulation Of Ras Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Lung Alveolus Development Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Protein Stabilization Regulation Of Protein Metabolic Process Myoblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Oocyte Development Growth Hormone Receptor Signaling Pathway Lung Vasculature Development Lung Lobe Morphogenesis Type I Pneumocyte Differentiation Type II Pneumocyte Differentiation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Glucose Stimulus Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Amyloid-beta Formation Positive Regulation Of Trophectodermal Cell Proliferation Cellular Response To Amyloid-beta Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Myoblast Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1	Platelet degranulation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Synthesis, secretion, and deacylation of Ghrelin
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE	N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Diseases		Tropical calcific pancreatitis	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Malignant pleural mesothelioma
GWAS		A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Birth weight ( 27680694 31043758) Brain morphology (MOSTest) ( 32665545) Cortical volume ( 32963231) Dental caries (decayed and filled deciduous teeth) ( 31533690) Fasting blood insulin ( 20081858 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting insulin ( 34059833) FEV1 ( 30804560) Height ( 34270706 19893584 31562340 31217584 20189936 25429064) Hip circumference adjusted for BMI ( 34021172) Homeostasis model assessment of insulin resistance ( 20081858) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Lung function (FVC) ( 30804560) Mammographic density (dense area) ( 25342443) Offspring birth weight ( 31043758) Peak expiratory flow ( 30804560) Refractive error ( 32231278) Response to quetiapine in schizophrenia ( 29503163) Systolic blood pressure ( 30224653) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1	22 interacting genes: BANP CCN3 CCN5 CTSB E2F1 ENKD1 IDE IGF1R IGFALS IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IGSF1 MESD MKRN3 SOX4 TCEANC TF
Entrez ID		1508	3479
HPRD ID		00287	00936
Ensembl ID		ENSG00000164733	ENSG00000017427
Uniprot IDs		A0A024R374 P07858	P05019 Q13429 Q59GC5 Q5U743
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN	1B9G 1BQT 1GZR 1GZY 1GZZ 1H02 1H59 1IMX 1PMX 1TGR 1WQJ 2DSP 2DSQ 2DSR 2GF1 3GF1 3LRI 4XSS 5U8Q 6FF3 6PYH 6RVA 7S0Q 7WRQ 7YRR 8EYR 8X06 8X2M 8XJS 8XK1 8XKM 8XKR
Enriched GO Terms of Interacting Partners?		Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding	Insulin-like Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Extracellular Region Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Extracellular Space Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Lumen Regulation Of Wnt Signaling Pathway Insulin-like Growth Factor Binding Protein Complex Negative Regulation Of Signal Transduction Fibronectin Binding Regulation Of Growth Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Signal Transduction Insulin Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Epithelial Cell Proliferation Insulin Receptor Signaling Pathway Signaling Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Amyloid-beta Clearance Hematopoietic Stem Cell Homeostasis Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Migration Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Beta-endorphin Binding Negative Regulation Of Skeletal Muscle Hypertrophy Insulin-like Growth Factor Binary Complex Response To Hormone Regulation Of MAPK Cascade Positive Regulation Of Myoblast Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Matrix Carbohydrate Homeostasis Glucose Homeostasis
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