CTSB and SERPINB13

Number of citations of the paper that reports this interaction (PubMedID 10512713)
0

Data Source:
HPRD (in vitro)

		CTSB	SERPINB13
Description		cathepsin B	serpin family B member 13
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen	Extracellular Space Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck Lysosomal Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Keratinocyte Apoptotic Process
Pathways		Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs		2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases		Tropical calcific pancreatitis
GWAS		A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)	Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1	9 interacting genes: CTSB CTSG CTSK CTSL DLG2 ELANE PLG PRSS1 PRTN3
Entrez ID		1508	5275
HPRD ID		00287	05118
Ensembl ID		ENSG00000164733	ENSG00000197641
Uniprot IDs		A0A024R374 P07858	A0A0A0MQW3 B7Z447 Q9UIV8
PDB IDs		1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN
Enriched GO Terms of Interacting Partners?		Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding	Peptidase Activity Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Extracellular Matrix Endolysosome Lumen Serine-type Peptidase Activity Collagen Catabolic Process Proteolysis Collagen Metabolic Process Extracellular Space Proteoglycan Binding Hydrolase Activity Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Biological Process Involved In Interaction With Symbiont Hormone Metabolic Process Leukocyte Migration Cysteine-type Endopeptidase Activity Collagen Binding Protein Metabolic Process Endopeptidase Activity Azurophil Granule Lumen Neutrophil-mediated Killing Of Bacterium Cellular Response To Thyroid Hormone Stimulus Thyroid Hormone Generation Cysteine-type Peptidase Activity Thyroid Hormone Metabolic Process Response To Thyroid Hormone Neutrophil Mediated Immunity Lysosome Protein Processing Regulation Of Hormone Levels Fibronectin Binding Killing By Host Of Symbiont Cells Extracellular Exosome Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Macromolecule Metabolic Process Defense Response To Fungus Response To Fungus Protein Maturation Biofilm Matrix Disassembly Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria External Side Of Plasma Membrane Regulation Of Biological Quality Leukocyte Mediated Cytotoxicity Apical Plasma Membrane
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