RNF40 and NCBP1

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RNF40	NCBP1
Description		ring finger protein 40	nuclear cap binding protein subunit 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal Complex Assembly Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation 7-methylguanosine MRNA Capping MRNA Processing RNA Catabolic Process MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Transport Defense Response To Virus Positive Regulation Of RNA Binding
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
Drugs
Diseases
GWAS		Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451	19 interacting genes: BNIP1 BNIP2 BNIP3 DSCR9 EIF4G1 EIF4G2 HNRNPF HNRNPH1 LINC01554 NCBP2 PSTPIP1 PTEN RNF10 RNF20 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		9810	4686
HPRD ID		07411	02717
Ensembl ID		ENSG00000103549	ENSG00000136937
Uniprot IDs		A8K6K1 O75150	Q09161
PDB IDs		8GUI 8GUJ 8IEJ	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding	Response To Oxygen-glucose Deprivation Regulation Of Translational Initiation HULC Complex Cap-dependent Translational Initiation Nuclear Envelope Multicellular Organismal Response To Stress Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Macromolecule Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Cell Cycle Response To Nutrient Levels Macromolecule Metabolic Process Negative Regulation Of Autophagy Regulation Of Mitotic Cell Cycle Translation Factor Activity, RNA Binding MRNA Binding Ubiquitin-specific Protease Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Cell Death Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Regulation Of Autophagy Protein Metabolic Process Mitochondrion Autophagosome Adaptor Activity Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Fear Response Behavioral Fear Response Behavioral Defense Response RNA Splicing Negative Regulation Of Synaptic Vesicle Clustering Proteolysis Involved In Protein Catabolic Process Cytoplasmic Side Of Nuclear Pore Perforant Pathway To Dendrate Granule Cell Synapse Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Spliceosomal Complex Regulation Of Translation RNA Binding Translation Initiation Factor Activity MRNA Processing Mitochondrial Outer Membrane Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Oxidative Stress Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
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