RNF40 and NCBP1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RNF40	NCBP1
Gene Name		ring finger protein 40, E3 ubiquitin protein ligase	nuclear cap binding protein subunit 1, 80kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex Neuron Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Syntaxin-1 Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Protein Homodimerization Activity	RNA Cap Binding RNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Histone H2B Ubiquitination	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping MRNA Cleavage MRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Gene Expression Viral Process Gene Silencing By RNA MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing NcRNA Metabolic Process MRNA Cis Splicing, Via Spliceosome Positive Regulation Of Viral Transcription
Pathways			mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Tat-mediated elongation of the HIV-1 transcript Cleavage of Growing Transcript in the Termination Region Processing of Intronless Pre-mRNAs RNA Polymerase II Pre-transcription Events SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs HIV Life Cycle Transport of Mature Transcript to Cytoplasm HIV Transcription Elongation SLBP independent Processing of Histone Pre-mRNAs Nonsense-Mediated Decay (NMD) Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Capping Transport of Mature mRNAs Derived from Intronless Transcripts mRNA Splicing - Minor Pathway Metabolism of non-coding RNA mRNA Splicing - Major Pathway mRNA 3'-end processing Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) snRNP Assembly Formation of HIV elongation complex in the absence of HIV Tat Processing of Capped Intronless Pre-mRNA Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Termination Transcription of the HIV genome Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Thyroid cancer (Papillary, radiation-related) ( 20350937)
Protein-Protein Interactions		18 interactors: AMOTL2 ATM CCDC146 CDC73 HIST2H2BE ITSN1 MSL1 NCBP1 RB1 SFR1 TRIM51 UBE2A UBE2B UBE2E1 UBE2I UBE2L6 WAC ZNF451	14 interactors: BNIP1 BNIP2 BNIP3 C17orf85 EIF4G1 EIF4G2 HNRNPF HNRNPH1 NCBP2 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		9810	4686
HPRD ID		07411	02717
Ensembl ID		ENSG00000103549	ENSG00000136937
Uniprot IDs		A8K6K1 F8W8Z4 O75150	Q09161
PDB IDs			1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Chromatin Organization Chromatin Modification Histone Modification Chromosome Organization Protein Monoubiquitination Histone H2B Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone Monoubiquitination Cellular Macromolecule Catabolic Process Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Metaphase/anaphase Transition ISG15-protein Conjugation Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Regulation Of Chromosome Organization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Modification-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Proteasomal Protein Catabolic Process Regulation Of Chromosome Segregation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Negative Regulation Of Chromosome Organization Cell Cycle Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Histone H2A Ubiquitination Positive Regulation Of MRNA 3'-end Processing Regulation Of MRNA 3'-end Processing Negative Regulation Of Protein Catabolic Process Cellular Protein Modification Process Regulation Of Mitotic Nuclear Division Catabolic Process Histone MRNA Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Postreplication Repair	Regulation Of Translational Initiation MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Regulation Of Translation RNA Splicing Posttranscriptional Regulation Of Gene Expression Cell Death Death Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Viral Process MRNA 3'-end Processing Cellular Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Fusion SnRNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of RNA Splicing Apoptotic Process Negative Regulation Of Cell Death RNA 3'-end Processing Positive Regulation By Virus Of Viral Protein Levels In Host Cell Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Mitochondrial Protein Catabolic Process Programmed Cell Death Catabolic Process Cellular Metabolic Process Skeletal Muscle Atrophy Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Viral Process RNA Localization Insulin Receptor Signaling Pathway Autophagic Cell Death Striated Muscle Atrophy Response To Leucine Regulation Of Mitochondrial Fusion Regulation Of Viral Process MRNA Catabolic Process Cellular Response To Cobalt Ion Muscle Atrophy RNA Catabolic Process Skeletal Muscle Adaptation Histone H2B Ubiquitination
Tagcloud ?		accessible alongside attracting deubiquitinases discoveries disrupt e3 fostering h2b h2bub1 h3k4 h3k79 ligases marking monoubiquitination parathyroid polyubiquitination ptm ptms recruiting rnf20 shed strands talk traditionally usp22 usp44 usp7 viewed	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Difference) ?		accessible alongside attracting deubiquitinases discoveries disrupt e3 fostering h2b h2bub1 h3k4 h3k79 ligases marking monoubiquitination parathyroid polyubiquitination ptm ptms recruiting rnf20 shed strands talk traditionally usp22 usp44 usp7 viewed	adaptation cdna delayed elicited equivalent fundamental heat implicates ischaemia ischaemic isoform lethal mediating modulating myocardium pp2 preconditioning rabbit rda rendered reperfusion representational salvage se sham shock tgfbeta trip1 ventricle
Tagcloud (Intersection) ?