RNF40 and DUSP29

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF40	DUSP29
Description		ring finger protein 40	dual specificity phosphatase 29
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Membrane HULC Complex	Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	MRNA 3'-UTR Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity MAP Kinase Phosphatase Activity Protein Homodimerization Activity
	Biological Process	Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Protein Dephosphorylation Glucose Homeostasis Muscle Cell Differentiation Negative Regulation Of MAPK Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		27 interacting genes: AMOTL2 ATM CCDC146 CDC73 DUSP29 EEF1D H2AC4 H2BC3 ITSN1 KIF11 MEOX2 MSL1 MTNR1B NCBP1 NINL PKNOX1 RB1 RPA1 RPA2 TRIM51 UBE2A UBE2B UBE2D2 UBE2I UBE2L6 ZCCHC12 ZNF451	25 interacting genes: AATK ARPC3 ASPA C17orf75 CNTROB DDIT4L EPHA2 ERBB3 GOLGA6A IGF1R LMTK2 LNX1 NIF3L1 NOC4L PICK1 POLR2G PSMB5 PTK7 RNF40 ROR1 ROR2 SRSF11 STX11 TCF4 TEPSIN
Entrez ID		9810	338599
HPRD ID		07411	16846
Ensembl ID		ENSG00000103549	ENSG00000188716
Uniprot IDs		A8K6K1 O75150	Q68J44
PDB IDs		8GUI 8GUJ 8IEJ	2Y96
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Localization To Chromosome PML Body Ubiquitin-like Protein Transferase Activity Chromosome, Telomeric Region Positive Regulation Of MRNA 3'-end Processing HULC Complex Chromatin Organization Nucleus Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Modification By Small Protein Conjugation Protein Polyubiquitination Telomere Localization Regulation Of MRNA 3'-end Processing G-rich Strand Telomeric DNA Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition DNA Replication Factor A Complex Chromosome Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Post-translational Protein Modification Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleoplasm Negative Regulation Of Cell Cycle Phase Transition Site Of Double-strand Break Chromatin Remodeling Telomere Maintenance Proteolysis Involved In Protein Catabolic Process Histone MRNA Metabolic Process Response To Radiation Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Localization To Site Of Double-strand Break Sperm Axoneme Assembly Negative Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Mismatch Repair Telomere Organization DNA Repair MRNA 3'-end Processing Double-strand Break Repair Via Homologous Recombination Ubiquitin Protein Ligase Binding Recombinational Repair Regulation Of DNA Recombination Positive Regulation Of RNA Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Kinase Activity Protein Tyrosine Kinase Activity Receptor Complex Kinase Activity Glial Cell Development Dendritic Spine Maintenance Coreceptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Transferase Activity ATP Binding
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