USP12

Description		ubiquitin specific peptidase 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability
Pathways		Ub-specific processing proteases
Drugs
Diseases
GWAS		Alcohol dependence ( 21314694) Anti-saccade response ( 29064472) Aspartate aminotransferase levels ( 33547301) Mortality in sepsis ( 27639821) Nose morphology ( 29921221) Ulcerative colitis ( 19915573)
Novel Interacting Genes		1 novel interacting genes: NUP58
Interacting Genes		9 interacting genes: APP BAX CDC73 H2AC20 H2BC21 HMGB1 NOTCH1 RRM2 UBC
Entrez ID		219333
HPRD ID		15631
Ensembl ID		ENSG00000152484
Uniprot IDs		O75317
PDB IDs		5K16 5K1A 5K1B 5K1C 5L8W
Enriched GO Terms of Interacting Partners?		Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis RAGE Receptor Binding Response To External Biotic Stimulus Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Nucleus Positive Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Morphogenesis Positive Regulation Of Apoptotic Process Chemoattractant Activity Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Development Epithelial Cell Proliferation Negative Regulation Of Fibroblast Proliferation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Programmed Cell Death Regulation Of Chemotaxis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Chemotaxis Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Humoral Immune Response T Cell Homeostatic Proliferation BAX Complex Release Of Matrix Enzymes From Mitochondria Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition
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