USP12 and RRM2

Number of citations of the paper that reports this interaction (PubMedID 37341611)
0

Data Source:
BioGRID (enzymatic study)

		USP12	RRM2
Description		ubiquitin specific peptidase 12	ribonucleotide reductase regulatory subunit M2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding Deubiquitinase Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Ferric Iron Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Proteolysis Protein Deubiquitination Regulation Of Protein Stability	Blastocyst Development Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleotide Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Ub-specific processing proteases	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs			Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Alcohol dependence ( 21314694) Anti-saccade response ( 29064472) Aspartate aminotransferase levels ( 33547301) Mortality in sepsis ( 27639821) Nose morphology ( 29921221) Ulcerative colitis ( 19915573)	Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)
Interacting Genes		9 interacting genes: APP BAX CDC73 H2AC20 H2BC21 HMGB1 NOTCH1 RRM2 UBC	10 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53 USP12
Entrez ID		219333	6241
HPRD ID		15631	01587
Ensembl ID		ENSG00000152484	ENSG00000171848
Uniprot IDs		O75317	P31350
PDB IDs		5K16 5K1A 5K1B 5K1C 5L8W	2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?		Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis RAGE Receptor Binding Response To External Biotic Stimulus Protein Heterodimerization Activity Regulation Of Epithelial Cell Proliferation Nucleus Positive Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Morphogenesis Positive Regulation Of Apoptotic Process Chemoattractant Activity Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Monocyte Chemotaxis Apoptotic Process Involved In Development Epithelial Cell Proliferation Negative Regulation Of Fibroblast Proliferation Inflammatory Response To Antigenic Stimulus Positive Regulation Of Programmed Cell Death Regulation Of Chemotaxis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Chemotaxis Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Macrophage Activation Regulation Of ERK1 And ERK2 Cascade Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Humoral Immune Response T Cell Homeostatic Proliferation BAX Complex Release Of Matrix Enzymes From Mitochondria Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Positive Regulation Of Cell Cycle G1/S Phase Transition	Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Mitochondrial DNA Metabolic Process Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Protein Transport Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G0 To G1 Transition Golgi Disassembly Regulation Of Mitotic Cell Cycle Positive Regulation Of Establishment Of Protein Localization Signal Transduction In Response To DNA Damage DNA-templated DNA Replication DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Mitotic Sister Chromatid Segregation Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Nuclear Membrane Disassembly Mitochondrial DNA Replication Organelle Disassembly Regulation Of Metaphase Plate Congression Regulation Of Cell Cycle Phase Transition Nuclear Membrane Disassembly Regulation Of Protein Transport Regulation Of Cell Cycle Process Positive Regulation Of Protein Localization Regulation Of Cell Cycle 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Membrane Disassembly Positive Regulation Of Intracellular Protein Transport DNA Biosynthetic Process Carbohydrate Derivative Biosynthetic Process Mitotic G1/S Transition Checkpoint Signaling Triglyceride Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process DNA Damage Response Signal Transduction By P53 Class Mediator DNA Repair Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Organization Positive Regulation Of Transport Regulation Of Establishment Of Protein Localization Regulation Of Circadian Rhythm Positive Regulation Of Cell Cycle Phase Transition Regulation Of Attachment Of Spindle Microtubules To Kinetochore RRNA Transcription Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction By P53 Class Mediator
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