MAP3K8 and ACY3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAP3K8	ACY3
Gene Name		mitogen-activated protein kinase kinase kinase 8	aspartoacylase (aminocyclase) 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Cytosol Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Molecular_function Aminoacylase Activity Hydrolase Activity, Acting On Ester Bonds Identical Protein Binding Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Regulation Of Cell Differentiation	Xenobiotic Metabolic Process Biological_process Viral Process Small Molecule Metabolic Process
Pathways		Signaling by Interleukins Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Cytokine Signaling in Immune system Interleukin-1 signaling Adaptive Immune System	Aflatoxin activation and detoxification Biological oxidations Metabolic disorders of biological oxidation enzymes Defective ACY1 causes encephalopathy
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	14 interactors: AAMDC ASPA GORASP2 KRTAP10-3 KRTAP10-8 LNX1 MAP3K8 NEDD4L NOTCH2NL PIAS2 PLEKHF2 PMM2 RARG RRAS
Entrez ID		1326	91703
HPRD ID		01863	12422
Ensembl ID		ENSG00000107968	ENSG00000132744
Uniprot IDs		P41279	Q96HD9
PDB IDs
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Immune Response Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Cytokine Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity
Tagcloud ?		10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity
Tagcloud (Difference) ?		10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity
Tagcloud (Intersection) ?