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MAP3K8 and MAP2K4
Number of citations of the paper that reports this interaction (PubMedID
8631303
)
60
Data Source:
HPRD
(in vitro)
MAP3K8
MAP2K4
Description
mitogen-activated protein kinase kinase kinase 8
mitogen-activated protein kinase kinase 4
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Nucleus
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Kinase Activity
Transferase Activity
Molecular Adaptor Activity
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Immune System Process
Protein Phosphorylation
Signal Transduction
T Cell Costimulation
Positive Regulation Of Inflammatory Response
MAPK Cascade
Apoptotic Process
Signal Transduction
JNK Cascade
Response To Wounding
Cellular Response To Stress
Smooth Muscle Cell Apoptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Fc-epsilon Receptor Signaling Pathway
Cellular Response To Mechanical Stimulus
Cellular Senescence
Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Pimasertib
Diseases
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
23128233
28067908
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
Asthma (
32296059
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
)
Interacting Genes
17 interacting genes:
ACY3
AKT1
BMPR2
CD40
CHUK
MAP2K1
MAP2K4
MAP3K14
NFKB1
NFKB2
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
44 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
ZDHHC17
Entrez ID
1326
6416
HPRD ID
01863
03213
Ensembl ID
ENSG00000107968
ENSG00000065559
Uniprot IDs
P41279
Q6FG25
P45985
PDB IDs
4Y83
4Y85
5IU2
3ALN
3ALO
3VUT
8YP5
Enriched GO Terms of Interacting Partners
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Non-canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Intracellular Signaling Cassette
Response To Cytokine
Response To Peptide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
CD40 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Receptor Complex
Intracellular Signal Transduction
Cell Surface Toll-like Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Signal Transduction
Cell Surface Pattern Recognition Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Cytokine Stimulus
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Oxygen-containing Compound
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Protein Kinase Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Inflammatory Response
Positive Regulation Of Immune System Process
Response To Stress
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cytokine Production
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Defense Response
Positive Regulation Of DNA-templated Transcription
NF-kappaB P50/p65 Complex
Positive Regulation Of Cytokine-mediated Signaling Pathway
Kinase Activity
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Interleukin-12 Production
Positive Regulation Of Response To Cytokine Stimulus
MAPK Cascade
MAP Kinase Kinase Kinase Activity
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Activity
Intracellular Signaling Cassette
Protein Kinase Activity
Kinase Activity
Regulation Of MAPK Cascade
Intracellular Signal Transduction
JNK Cascade
MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
ATP Binding
Protein Phosphorylation
Positive Regulation Of Intracellular Signal Transduction
Phosphorylation
Transferase Activity
Stress-activated MAPK Cascade
Signal Transduction
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Cytoplasm
Regulation Of Signal Transduction
Nucleotide Binding
JUN Kinase Kinase Kinase Activity
Protein Modification Process
Cytosol
P38MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Protein Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of JNK Cascade
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Modification Process
Positive Regulation Of JNK Cascade
Cellular Senescence
JUN Kinase Activity
Regulation Of MAP Kinase Activity
Phosphate-containing Compound Metabolic Process
Protein Autophosphorylation
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Protein Modification Process
Regulation Of Programmed Cell Death
Immune Response-regulating Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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