MAP3K8 and MAP2K1

Number of citations of the paper that reports this interaction (PMID 8631303)
68

Data Source:
BioGRID (enzymatic study, enzymatic study)

		MAP3K8	MAP2K1
Gene Name		mitogen-activated protein kinase kinase kinase 8	mitogen-activated protein kinase kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Microtubule Organizing Center Cytosol Microtubule Plasma Membrane Focal Adhesion Cell Cortex Axon Dendrite Cytoplasm Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Phosphatase Activity Protein Binding ATP Binding Ras GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Regulation Of Cell Differentiation	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Vascular Smooth Muscle Contraction Movement Of Cell Or Subcellular Component Chemotaxis Response To Oxidative Stress Cell Cycle Arrest Mitotic Nuclear Division Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Pathogenesis Positive Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Ras GTPase Activity Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Homotypic Cell-cell Adhesion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Golgi Inheritance Response To Axon Injury Cell Motility Protein Heterooligomerization Response To Glucocorticoid Stress-activated MAPK Cascade Placenta Blood Vessel Development Labyrinthine Layer Development Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Early Endosome To Late Endosome Transport
Pathways		Signaling by Interleukins Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Cytokine Signaling in Immune system Interleukin-1 signaling Adaptive Immune System	Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Uptake and actions of bacterial toxins Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling Uptake and function of anthrax toxins SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling ERK1 activation SHC-related events triggered by IGF1R GRB2 events in EGFR signaling ERK1 activation Signaling by ERBB4 Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-1 signaling Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events ERK activation Axon guidance IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade L1CAM interactions IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling IRS-related events triggered by IGF1R MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation RAF phosphorylates MEK Downstream signaling of activated FGFR TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Signal transduction by L1 Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events MyD88-independent cascade Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs			K-252a 5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		17 interactors: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	41 interactors: ARAF BANP BIRC6 BRAF CASP9 CDK5 CPNE1 CPNE4 EGFR ELK1 EP300 GRB10 HNRNPD HRAS KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MYC PAK1 PARVA PEBP1 PEBP4 PLK3 PPARG PRKCI PRKCZ RAF1 RPS6KA2 RPS6KA4 SUMO1 TRAF3 TRAF6 TRIB1 WNK1
Entrez ID		1326	5604
HPRD ID		01863	01469
Ensembl ID		ENSG00000107968
Uniprot IDs		P41279	A4QPA9 B4DFY5 Q02750
PDB IDs			1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Immune Response Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Cytokine Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity	Regulation Of Protein Metabolic Process MAPK Cascade Signal Transduction By Phosphorylation Regulation Of Cellular Protein Metabolic Process Phosphorylation Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of MAPK Cascade Activation Of Protein Kinase Activity Cellular Response To Organic Substance Regulation Of Signal Transduction Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Programmed Cell Death Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Cellular Response To Growth Factor Stimulus Cell Death Death Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Response To Growth Factor Positive Regulation Of Kinase Activity Signaling Cellular Protein Modification Process Regulation Of Kinase Activity Signal Transduction Cell Communication Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity
Tagcloud ?		10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity	actionable adenocarcinomas akt1 alk braf capture ccdc6 cd74 clip4 deemed driver fusions g719a genomic introns kif5b nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?