MAP3K8 and TNIP2

Number of citations of the paper that reports this interaction (PubMedID 15169888)
33

Data Source:
HPRD (in vitro, in vivo)

		MAP3K8	TNIP2
Description		mitogen-activated protein kinase kinase kinase 8	TNFAIP3 interacting protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Zinc Ion Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 33536424)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	28 interacting genes: APP BACE1 CACNA1C CDKN1A CLK1 EP300 FBXO25 FLNA FXR2 IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PSMD9 REL RELA SHANK3 SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC
Entrez ID		1326	79155
HPRD ID		01863	18207
Ensembl ID		ENSG00000107968	ENSG00000168884
Uniprot IDs		P41279 Q6FG25	D6RGJ2 Q8NFZ5
PDB IDs		4Y83 4Y85 5IU2	5H07
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus	Intracellular Signaling Cassette Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Primary Metabolic Process Cytosol NF-kappaB P50/p65 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein Serine/threonine Kinase Binding Signal Transduction Response To UV-B Positive Regulation Of Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Defense Response Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Nucleus Response To Lipopolysaccharide Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process NF-kappaB Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Protein Serine Kinase Activity Response To Cytokine Regulation Of Immune System Process Regulation Of Gene Expression Response To Peptide Positive Regulation Of Neurogenesis
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