MAP3K8 and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro)

		MAP3K8	NFKB2
Description		mitogen-activated protein kinase kinase kinase 8	nuclear factor kappa B subunit 2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MAPK Cascade Immune System Process Protein Phosphorylation Signal Transduction T Cell Costimulation Positive Regulation Of Inflammatory Response	Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction Extracellular Matrix Organization Response To Lipopolysaccharide Response To Cytokine Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Intracellular Signaling Cassette
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection Regulation of PD-L1(CD274) transcription
Drugs			Sulfasalazine Donepezil Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233 28067908) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Metabolite levels ( 23823483) Refractive error ( 32231278) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		1326	4791
HPRD ID		01863	01239
Ensembl ID		ENSG00000107968	ENSG00000077150
Uniprot IDs		P41279 Q6FG25	Q00653
PDB IDs		4Y83 4Y85 5IU2	1A3Q 2D96 3DO7 4OT9 5ZMC 7CLI 7VUP 7VUQ 7W7L 8G8Q 8G8S
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Intracellular Signaling Cassette Response To Cytokine Response To Peptide Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor CD40 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Cellular Response To Oxygen-containing Compound Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Kinase Activity Positive Regulation Of DNA-binding Transcription Factor Activity Inflammatory Response Positive Regulation Of Immune System Process Response To Stress Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Defense Response Positive Regulation Of DNA-templated Transcription NF-kappaB P50/p65 Complex Positive Regulation Of Cytokine-mediated Signaling Pathway Kinase Activity Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Interleukin-12 Production Positive Regulation Of Response To Cytokine Stimulus	Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Canonical NF-kappaB Signal Transduction Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Inflammatory Response Regulation Of Gene Expression Immune System Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Defense Response Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Response To External Biotic Stimulus Immune Response-activating Signaling Pathway Negative Regulation Of Biosynthetic Process Cytoplasm Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Nucleoplasm Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Innate Immune Response Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of Defense Response NF-kappaB Complex Pattern Recognition Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process
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