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MAP3K8
Description
mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Immune System Process
Protein Phosphorylation
Signal Transduction
T Cell Costimulation
Positive Regulation Of Inflammatory Response
Pathways
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
23128233
28067908
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
Novel Interacting Genes
9 novel interacting genes:
ACP6
ADAM10
GAD2
JCAD
LYZL2
MTPAP
PARD3
PDK2
RANGAP1
Interacting Genes
17 interacting genes:
ACY3
AKT1
BMPR2
CD40
CHUK
MAP2K1
MAP2K4
MAP3K14
NFKB1
NFKB2
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
Entrez ID
1326
HPRD ID
01863
Ensembl ID
ENSG00000107968
Uniprot IDs
P41279
Q6FG25
PDB IDs
4Y83
4Y85
5IU2
Enriched GO Terms of Interacting Partners
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Non-canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Intracellular Signaling Cassette
Response To Cytokine
Response To Peptide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
CD40 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Receptor Complex
Intracellular Signal Transduction
Cell Surface Toll-like Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Signal Transduction
Cell Surface Pattern Recognition Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Cytokine Stimulus
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Oxygen-containing Compound
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Protein Kinase Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Inflammatory Response
Positive Regulation Of Immune System Process
Response To Stress
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cytokine Production
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Defense Response
Positive Regulation Of DNA-templated Transcription
NF-kappaB P50/p65 Complex
Positive Regulation Of Cytokine-mediated Signaling Pathway
Kinase Activity
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Interleukin-12 Production
Positive Regulation Of Response To Cytokine Stimulus
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