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MAP3K8 and CD40
Number of citations of the paper that reports this interaction (PubMedID
15670770
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
MAP3K8
CD40
Description
mitogen-activated protein kinase kinase kinase 8
CD40 molecule
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Region
Extracellular Space
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
CD40 Receptor Complex
Neuronal Cell Body
Varicosity
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Antigen Binding
Protein Binding
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Biological Process
MAPK Cascade
Immune System Process
Protein Phosphorylation
Signal Transduction
T Cell Costimulation
Positive Regulation Of Inflammatory Response
Immune System Process
Regulation Of Immunoglobulin Production
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Intracellular Calcium Ion Homeostasis
Defense Response
Inflammatory Response
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Bacterium
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
B Cell Mediated Immunity
CD40 Signaling Pathway
Platelet Activation
Positive Regulation Of B Cell Proliferation
Response To Nutrient Levels
Positive Regulation Of Interleukin-12 Production
Response To Cobalamin
Response To Type II Interferon
Cellular Response To Erythropoietin
B Cell Proliferation
B Cell Activation
Defense Response To Protozoan
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Isotype Switching To IgG Isotypes
Regulation Of Immune Response
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein-containing Complex Assembly
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Protein Kinase C Signaling
Response To Peptide
Positive Regulation Of Interleukin-4-mediated Signaling Pathway
Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Lucatumumab
Dacetuzumab
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS
Asthma (
32296059
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
23128233
28067908
)
Systemising (
31508503
)
Ulcerative colitis (
28067908
)
Blood protein levels in cardiovascular risk (
28369058
)
Chronic hepatitis B infection (
25802187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Hodgkin's lymphoma (
30194254
)
Inflammatory bowel disease (
23128233
28067908
)
Kawasaki disease (
33106546
22446961
22446962
)
Multiple sclerosis (
19525955
24076602
22190364
21833088
)
Rheumatoid arthritis (
24390342
23143596
30423114
18794853
)
Rheumatoid arthritis (ACPA-positive) (
24532676
23143596
)
Systemic lupus erythematosus (
28714469
)
Tonsillectomy (
27182965
28928442
)
Interacting Genes
17 interacting genes:
ACY3
AKT1
BMPR2
CD40
CHUK
MAP2K1
MAP2K4
MAP3K14
NFKB1
NFKB2
REL
RELA
RIPK1
STIP1
TNIP2
TRAF2
TRAF6
44 interacting genes:
BIRC2
BIRC3
CAV1
CBL
CD40LG
CMTM5
CMTM6
CYB561A3
DEFB121
EBP
FAF1
HSPA4
HSPA8
IL4R
INSIG2
JAK3
MAL
MAP3K8
MIP
MS4A1
NCOA6
NSMAF
PIK3R1
PLP1
RIPK2
SLC30A2
SLC30A3
SLC39A13
SLC61A1
SLC7A1
TANK
TDP2
TLCD1
TMEM107
TMEM128
TMEM147
TRAF1
TRAF2
TRAF3
TRAF3IP2
TRAF5
TRAF6
XRCC5
XRCC6
Entrez ID
1326
958
HPRD ID
01863
00178
Ensembl ID
ENSG00000107968
ENSG00000101017
Uniprot IDs
P41279
Q6FG25
A0A0S2Z349
A0A0S2Z3C7
A0A8Q3SI60
P25942
Q6P2H9
PDB IDs
4Y83
4Y85
5IU2
1CZZ
1D00
1FLL
1LB6
3QD6
5DMI
5DMJ
5IHL
6FAX
6PE8
6PE9
7P3I
8YX1
8YX9
Enriched GO Terms of Interacting Partners
?
Non-canonical NF-kappaB Signal Transduction
Canonical NF-kappaB Signal Transduction
Intracellular Signaling Cassette
Response To Cytokine
Response To Peptide
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Tumor Necrosis Factor
CD40 Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Receptor Complex
Intracellular Signal Transduction
Cell Surface Toll-like Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Signal Transduction
Cell Surface Pattern Recognition Receptor Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Cytokine Stimulus
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Cellular Response To Oxygen-containing Compound
Signal Transduction
Toll-like Receptor 4 Signaling Pathway
Protein Kinase Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Inflammatory Response
Positive Regulation Of Immune System Process
Response To Stress
Immune Response-activating Cell Surface Receptor Signaling Pathway
Protein Serine/threonine Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cytokine Production
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of RNA Biosynthetic Process
Defense Response
Positive Regulation Of DNA-templated Transcription
NF-kappaB P50/p65 Complex
Positive Regulation Of Cytokine-mediated Signaling Pathway
Kinase Activity
Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Regulation Of Interleukin-12 Production
Positive Regulation Of Response To Cytokine Stimulus
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
CD40 Signaling Pathway
CD40 Receptor Complex
Tumor Necrosis Factor Receptor Binding
Thioesterase Binding
Interleukin-17-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Signaling Adaptor Activity
Cell Surface Receptor Signaling Pathway
Response To Stress
Regulation Of Immune Response
Regulation Of Innate Immune Response
Cytoplasmic Side Of Plasma Membrane
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Immune System Process
Positive Regulation Of Protein Modification Process
Response To Other Organism
Positive Regulation Of Post-translational Protein Modification
Non-canonical NF-kappaB Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Defense Response
Defense Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Immune System Process
Immune Response
Positive Regulation Of Lymphocyte Activation
Regulation Of Apoptotic Process
Toll-like Receptor 4 Signaling Pathway
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ubiquitin Protein Ligase Activity
Regulation Of Extrinsic Apoptotic Signaling Pathway
Protein-containing Complex
Protein Binding
CD40 Receptor Binding
Defense Response To Other Organism
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Immune System Process
Regulation Of Programmed Cell Death
Response To External Biotic Stimulus
Innate Immune Response
Positive Regulation Of Protein Ubiquitination
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of DNA-binding Transcription Factor Activity
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Tagcloud (Intersection)
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