APOC3 and ERGIC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOC3	ERGIC3
Description		apolipoprotein C3	ERGIC and golgi 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Retrograde Transporter Complex, Golgi To ER Transporter Complex
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Triglyceride Homeostasis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport Positive Regulation Of Intracellular Protein Transport
Pathways		Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Copper Volanesorsen
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28270201 19060906 26582766 20864672 30275531 20686565) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 20864672 20686565 19060911 18179892) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 30576415 24386095) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 22916037) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Postprandial triglyceride levels ( 32603185) Red cell distribution width ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Triglyceride levels ( 26763881 28334899 28371326 28548082) Triglycerides ( 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193044 18193043)	Apolipoprotein B levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 25961943 20686565) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196 34021172) LDL cholesterol levels ( 32203549) Refractive error ( 32231278) Schizophrenia ( 28991256) Total cholesterol levels ( 28334899 30275531) Triglycerides ( 25961943) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: ARFGAP1 ERGIC3 FAM209A GPX8 SNCA SOX4 VKORC1	233 interacting genes: ABHD16A ADGRE2 ADIPOQ AGPAT4 AGTRAP AIG1 ALG10 AOC2 APOC3 APOD APOL2 AQP10 AQP2 AQP3 ARLN ASGR1 ATP13A1 ATP1B4 ATP6V0C BCL2L1 BET1 BIK BNIP3 BTN2A2 BUD31 C14orf180 C2 C3orf52 CCDC167 CCR2 CCR4 CCR8 CD207 CD302 CD81 CDIPT CDS2 CEBPA CFHR5 CHRM4 CIAO2A CLCA4 CLDN19 CLDN8 CLDND2 CMTM5 CNIH1 CNIH3 COL4A5 COX20 CTSA CTXN3 CXorf66 CYB561 CYB561D2 CYB5B CYBC1 CYP4F2 DEFB103A DEFB103B EBP EMC6 EMP1 EMP3 ENTPD3 ERG28 ERGIC1 EXTL1 F2RL1 FA2H FAM3C FAXDC2 FETUB FIS1 FKBP8 FUNDC2 FXYD2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GOSR2 GPM6B GPR151 GPR152 GPR35 GPR37 GYPA HHATL HMOX1 HMOX2 IFITM3 IGFBP5 INSIG2 ITGAM JAGN1 KCNK1 LHFPL5 LPAR3 LPCAT2 MALL MARCHF2 MARCHF5 MFF MFSD6 MIP MS4A13 MYADM NDRG4 NDUFB6 NEU1 NINJ2 NKG7 NRG4 NRM NSG1 OGT ORMDL1 ORMDL2 ORMDL3 PAQR5 PAQR7 PEX11G PEX16 PGAP2 PLLP PLN PLP1 PLPP4 PMP22 PNLIPRP1 POMGNT1 RFT1 RHAG RTP2 RUSF1 SCARB2 SCD SEC22B SEC23A SELENOK SERP2 SFXN5 SLC13A3 SLC1A1 SLC29A2 SLC30A2 SLC35A1 SLC35A4 SLC35B2 SLC35B4 SLC38A7 SLC41A1 SLC41A2 SLC49A3 SMAGP SMCO4 SMIM1 SMIM3 SNCA SNORC SPN STATH STRIT1 STX12 STX1B STX3 STX8 SYNGR1 SYNJ2BP SYS1 TAP1 TECR TF THBD TM4SF4 TMEM100 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM140 TMEM141 TMEM147 TMEM14A TMEM14B TMEM179B TMEM203 TMEM218 TMEM222 TMEM229B TMEM243 TMEM254 TMEM42 TMEM60 TMEM65 TMEM86A TMEM86B TMEM97 TMUB2 TNFRSF10C TOMM6 TRAM1L1 TRARG1 TREX1 TRIM32 TSPAN33 TSPO2 UBIAD1 UNC50 UNC93B1 UPK1B VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VKORC1L1 VMP1 VSTM1 VTI1B YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC15 ZDHHC21 ZFPL1
Entrez ID		345	51614
HPRD ID		00132	15306
Ensembl ID		ENSG00000110245	ENSG00000125991
Uniprot IDs		A3KPE2 P02656	A2TJK5 Q9Y282
PDB IDs		2JQ3
Enriched GO Terms of Interacting Partners?		Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Localization Retrograde Transporter Complex, Golgi To ER Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Oxidoreductase Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Ascending Aorta Morphogenesis Pro-B Cell Differentiation Transporter Complex Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Transport Atrial Septum Primum Morphogenesis Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Cellular Response To Oxidative Stress Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Gamma-delta T Cell Differentiation Noradrenergic Neuron Differentiation Mitral Valve Morphogenesis Catecholamine Uptake Dopamine Uptake Regulation Of Protein Localization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Supramolecular Fiber Positive Regulation Of Gamma-delta T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Plasma Membrane Establishment Of Protein Localization To Membrane Endomembrane System Vesicle Fusion Golgi Membrane Organelle Membrane Fusion Organelle Fusion Vesicle-mediated Transport Localization Within Membrane Chemical Homeostasis Membrane Fusion Protein Localization To Membrane Membrane Organization SNARE Complex Assembly Protein Localization To Cell Periphery Establishment Of Protein Localization Establishment Of Protein Localization To Plasma Membrane Mitochondrial Outer Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Transmembrane Transport SNARE Binding Cellular Localization Membrane Docking Cholesterol Binding Bleb Assembly Structural Constituent Of Myelin Sheath Vesicle Organization Organelle Localization By Membrane Tethering Transport Vesicle Protein Localization To Plasma Membrane Intracellular Chemical Homeostasis Vesicle-mediated Transport To The Plasma Membrane Vesicle Docking Golgi Apparatus Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Homeostatic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Water Channel Activity Endosome To Plasma Membrane Protein Transport Golgi Vesicle Transport Mitochondrial Membrane Myelination Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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