APOC3

Name	apolipoprotein C3
Structure
Interactors	7 interactors: ARFGAP1 ERGIC3 FAM209A GPX8 SNCA SOX4 VKORC1
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	Protein Binding Phospholipid Binding Lipid Binding Cholesterol Binding Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Lipid Catabolic Process Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Triglyceride Homeostasis
Pathways	Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs	Copper Volanesorsen
GWAS	Blood protein levels ( 30072576 ) Body mass index ( 31978080 ) Cholesterol, total ( 19060911 20686565 ) Coronary heart disease ( 21378990 ) Delirium ( 29631748 ) Fasting triglyceride levels ( 32603185 ) HDL cholesterol ( 28270201 19060906 26582766 20864672 30275531 20686565 ) HDL cholesterol levels ( 28334899 ) Hematological and biochemical traits ( 20139978 ) High density lipoprotein cholesterol levels ( 28548082 ) Hypertriglyceridemia ( 23505323 ) LDL cholesterol ( 20864672 20686565 19060911 18179892 ) LDL cholesterol levels ( 28334899 ) Lipid metabolism phenotypes ( 22286219 ) Lipid traits ( 30576415 24386095 ) Lipoprotein (a) - cholesterol levels ( 25575512 ) Metabolite levels ( 22916037 ) Platelet count ( 27863252 ) Plateletcrit ( 27863252 32888494 ) Postprandial triglyceride levels ( 32603185 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Total cholesterol levels ( 28334899 ) Triglyceride levels ( 26763881 28334899 28371326 28548082 ) Triglycerides ( 26582766 21909109 20864672 20686565 20139978 19074352 19060911 19060906 18193044 18193043 )
Entrez ID	345
HPRD ID	00132
Ensembl ID	ENSG00000110245
Uniprot IDs	A3KPE2 P02656
PDB IDs	2JQ3
GO Terms Enriched among Interactors ?	Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Localization Retrograde Transporter Complex, Golgi To ER Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Oxidoreductase Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Ascending Aorta Morphogenesis Pro-B Cell Differentiation Transporter Complex Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Transport Atrial Septum Primum Morphogenesis Dopamine Uptake Involved In Synaptic Transmission Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Cellular Response To Oxidative Stress Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Positive Regulation Of Gamma-delta T Cell Differentiation Noradrenergic Neuron Differentiation Mitral Valve Morphogenesis Catecholamine Uptake Dopamine Uptake Regulation Of Protein Localization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Supramolecular Fiber Positive Regulation Of Gamma-delta T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Protein Transport