APOC3 and ARFGAP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		APOC3	ARFGAP1
Gene Name		apolipoprotein C-III	ADP-ribosylation factor GTPase activating protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome	Cytosol Golgi-associated Vesicle Membrane Synapse
	Molecular Function	Phospholipid Binding Cholesterol Binding Enzyme Regulator Activity Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding	GTPase Activator Activity Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Retinoid Metabolic Process Triglyceride Metabolic Process Triglyceride Mobilization Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Nutrient Phototransduction, Visible Light Cholesterol Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Lipoprotein Transport Response To Peptide Hormone Reverse Cholesterol Transport Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Cholesterol Import Triglyceride Homeostasis Cellular Response To Glucose Stimulus	Retrograde Vesicle-mediated Transport, Golgi To ER Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Transport Endoplasmic Reticulum Unfolded Protein Response Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process COPI Coating Of Golgi Vesicle Membrane Organization
Pathways		Lipoprotein metabolism HDL-mediated lipid transport Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport	IRE1alpha activates chaperones COPI Mediated Transport XBP1(S) activates chaperone genes Golgi to ER Retrograde Transport Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) HDL cholesterol ( 20864672 19060906 20686565) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolite levels ( 22916037) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565)
Protein-Protein Interactions		3 interactors: ARFGAP1 UBC VKORC1	31 interactors: APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23
Entrez ID		345	55738
HPRD ID		00132	06443
Ensembl ID		ENSG00000110245	ENSG00000101199
Uniprot IDs		A3KPE2 P02656	B7Z3U0 B7Z8H8 E7EV62 Q53F62 Q8N6T3
PDB IDs		2JQ3	3DWD 3O47
Enriched GO Terms of Interacting Partners?		Vitamin K Metabolic Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Viral Protein Processing COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Transferase Activity Golgi Vesicle Budding Positive Regulation Of Protein Phosphorylation Notch Receptor Processing Regulation Of Protein Kinase Activity Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Kinase Activity Glycogen Biosynthetic Process Intracellular Transport Of Virus Vesicle Targeting, To, From Or Within Golgi Membrane Organization Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Retrograde Vesicle-mediated Transport, Golgi To ER Quinone Metabolic Process Drug Metabolic Process Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Localization Within Membrane Vesicle Targeting Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of ERBB Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition	Triglyceride Catabolic Process Acylglycerol Catabolic Process Vesicle-mediated Transport COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Response To Extracellular Stimulus Protein-lipid Complex Assembly Protein Transport Establishment Of Protein Localization Plasma Lipoprotein Particle Remodeling Cholesterol Efflux Cellular Component Assembly Triglyceride Metabolic Process Protein Localization Vesicle Targeting, To, From Or Within Golgi Neutral Lipid Metabolic Process Response To Nutrient Levels Cholesterol Metabolic Process Plasma Lipoprotein Particle Clearance Sterol Metabolic Process Localization Within Membrane Vesicle Targeting Autophagic Vacuole Assembly Transport Cellular Lipid Catabolic Process Autophagy Regulation Of Catalytic Activity Response To Light Stimulus Macroautophagy Triglyceride Mobilization Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Membrane Organization Regulation Of Plasma Lipoprotein Particle Levels Low-density Lipoprotein Particle Remodeling Cholesterol Transport Sterol Transport Glycerolipid Metabolic Process Negative Regulation Of Cholesterol Transport Regulation Of Signaling Phospholipid Efflux Negative Regulation Of Hydrolase Activity Endocytosis Regulation Of Protein Processing Regulation Of Proteolysis Phototransduction, Visible Light Cholesterol Homeostasis Cellular Response To Extracellular Stimulus Sterol Homeostasis
Tagcloud ?		19x allele amish architecture atherosclerotic cardio conferring epidemiology ethnic ethnicity founder genomics genotyped geometric indiana lipoprotein means nhanes noncarrier nutrition ohio pennsylvania r19x racial rs76353203 subclinical surveys triglyceride triglycerides	accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Difference) ?		19x allele amish architecture atherosclerotic cardio conferring epidemiology ethnic ethnicity founder genomics genotyped geometric indiana lipoprotein means nhanes noncarrier nutrition ohio pennsylvania r19x racial rs76353203 subclinical surveys triglyceride triglycerides	accelerated adaptors adp associates cargo cathepsin cation cimpr clathrin copi ear endosomes exit explaining gga ggas golgi mannose perturbed rescued retrograde ribosylation slowed sorting traffic
Tagcloud (Intersection) ?