PAFAH1B1 and DNAI1

Number of citations of the paper that reports this interaction (PubMedID 11889140)
46

Data Source:
HPRD (in vivo)

		PAFAH1B1	DNAI1
Description		platelet activating factor acetylhydrolase 1b regulatory subunit 1	dynein axonemal intermediate chain 1
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GO Annotations	Cellular Component	Astral Microtubule Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Cell Leading Edge Motile Cilium Nuclear Membrane Vesicle Stereocilium Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Axon Cytoplasm	Extracellular Region Cytoplasm Centrosome Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton Dynein Complex Outer Dynein Arm Cell Projection Glial Cell Projection 9+2 Motile Cilium Dynein Axonemal Particle
	Molecular Function	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding	Cytoskeletal Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Microtubule-based Process Nuclear Migration JNK Cascade Chemical Synaptic Transmission Germ Cell Development Nervous System Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Cell Migration Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Positive Regulation Of Cellular Component Organization Cell Division Establishment Of Localization In Cell Establishment Of Organelle Localization Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Myeloid Leukocyte Migration Regulation Of Postsynapse Organization Radial Glia-guided Pyramidal Neuron Migration Interneuron Migration	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Heart Development Insulin Receptor Signaling Pathway Cell Projection Organization Flagellated Sperm Motility Outer Dynein Arm Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS		Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)	Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
Interacting Genes		26 interacting genes: CLIP1 CRYAA CSNK2A1 CUL4A CUL4B DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D SLC25A21-AS1 TNIK TUBA1A	2 interacting genes: PAFAH1B1 SQSTM1
Entrez ID		5048	27019
HPRD ID		03329	05080
Ensembl ID		ENSG00000007168	ENSG00000122735
Uniprot IDs		A0A6Q8PFT2 A0A6Q8PFU3 P43034	A0A087WWV9 A0A140VJI0 Q9UI46
PDB IDs		7MT1 8DYU 8DYV 8FDT 8FDU 8PQW 8PQY 8PQZ 8PTK	8J07
Enriched GO Terms of Interacting Partners?		Microtubule Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule Binding Cytoskeleton Cytoskeleton Organization Microtubule Associated Complex Organelle Localization Cytosol Cytoplasm Neuron Migration Establishment Of Organelle Localization Chromosome Localization Centrosome Regulation Of Microtubule Polymerization Or Depolymerization Organelle Organization Microtubule-based Transport Spindle Nervous System Development Microtubule-based Movement Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Cytoskeleton Neuron Projection Morphogenesis Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Cell Projection Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Kinetochore Transport Along Microtubule Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Organelle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Protein Heterodimerization Activity Positive Regulation Of Microtubule Polymerization Establishment Of Vesicle Localization Dynein Complex Establishment Of Mitotic Spindle Orientation Basal Dendrite Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Establishment Of Mitotic Spindle Localization Vesicle Localization Mitotic Centrosome Separation Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendrite Development Establishment Of Spindle Orientation Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Axon Hillock	Autophagy Of Mitochondrion DNA-templated Transcription Positive Regulation Of Macrophage Apoptotic Process Nucleobase-containing Compound Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of Protein Ubiquitination Stem Cell Division Protein K63-linked Ubiquitination Autophagy Cell Population Proliferation Ligase Inhibitor Activity Negative Regulation Of Post-translational Protein Modification Apoptotic Process Involved In Mammary Gland Involution Stem Cell Population Maintenance Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Glycine Catabolic Process Response To Methylamine Limb Morphogenesis Cumulus Cell Differentiation Natriuretic Peptide Receptor Activity Vestibulocochlear Nerve Maturation Nerve Maturation C-di-GMP Signaling Granulosa Cell Differentiation Activation Of Meiosis Involved In Egg Activation Neuromuscular Process Gastric Emptying Negative Regulation Of Oocyte Maturation Microtubule Sliding 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Forebrain Development Astral Microtubule Hippocampus Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Central Region Of Growth Cone Neural Plate Development Central Nervous System Segmentation Determination Of Left/right Asymmetry In Nervous System Mitophagy Brown Fat Cell Proliferation Amphisome Atg12 Transferase Activity Atg12 Conjugating Enzyme Activity Maintenance Of Cell Number Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution
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