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PAFAH1B1 and DCTN1
Number of citations of the paper that reports this interaction (PubMedID
27173435
)
70
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
PAFAH1B1
DCTN1
Description
platelet activating factor acetylhydrolase 1b regulatory subunit 1
dynactin subunit 1
Image
GO Annotations
Cellular Component
Astral Microtubule
Kinetochore
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Spindle
Cytosol
Cytoskeleton
Kinesin Complex
Microtubule
Microtubule Associated Complex
Cytoplasmic Microtubule
Cell Cortex
1-alkyl-2-acetylglycerophosphocholine Esterase Complex
Microtubule Cytoskeleton
Membrane
Axon
Growth Cone
Cell Leading Edge
Motile Cilium
Nuclear Membrane
Vesicle
Stereocilium
Neuron Projection
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Central Region Of Growth Cone
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Axon Cytoplasm
Kinetochore
Spindle Pole
Nucleus
Nuclear Envelope
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Cytoskeleton
Microtubule
Microtubule Associated Complex
Cilium
Cell Cortex
Microtubule Cytoskeleton
Membrane
Dynein Complex
Axon
Retromer Complex
Cell Leading Edge
Protein-containing Complex
Microtubule Plus-end
Ciliary Basal Body
Neuron Projection
Neuronal Cell Body
Intercellular Bridge
Mitotic Spindle
Cell Cortex Region
Centriolar Subdistal Appendage
Molecular Function
Protein Binding
Microtubule Binding
Heparin Binding
Dynactin Binding
Identical Protein Binding
Phospholipase Binding
Protein-containing Complex Binding
Dynein Intermediate Chain Binding
Protein Heterodimerization Activity
Microtubule Plus-end Binding
Phosphoprotein Binding
Dynein Complex Binding
Protein Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Tau Protein Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Ameboidal-type Cell Migration
Acrosome Assembly
Neuron Migration
Positive Regulation Of Cytokine-mediated Signaling Pathway
Lipid Metabolic Process
Microtubule-based Process
Nuclear Migration
JNK Cascade
Chemical Synaptic Transmission
Germ Cell Development
Nervous System Development
Neuroblast Proliferation
Learning Or Memory
Retrograde Axonal Transport
Adult Locomotory Behavior
Protein Secretion
Negative Regulation Of Neuron Projection Development
Lipid Catabolic Process
Cell Migration
Stem Cell Division
Transmission Of Nerve Impulse
Corpus Callosum Morphogenesis
Hippocampus Development
Layer Formation In Cerebral Cortex
Cerebral Cortex Neuron Differentiation
Cerebral Cortex Development
Actin Cytoskeleton Organization
Cell Differentiation
Forebrain Development
Microtubule Organizing Center Organization
Osteoclast Development
Reelin-mediated Signaling Pathway
Positive Regulation Of Embryonic Development
Establishment Of Planar Polarity Of Embryonic Epithelium
Cortical Microtubule Organization
Positive Regulation Of Axon Extension
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of JNK Cascade
Platelet Activating Factor Metabolic Process
Vesicle Transport Along Microtubule
Brain Morphogenesis
Modulation Of Chemical Synaptic Transmission
Neuromuscular Process Controlling Balance
Microtubule Sliding
Nuclear Membrane Disassembly
Positive Regulation Of Cellular Component Organization
Cell Division
Establishment Of Localization In Cell
Establishment Of Organelle Localization
Establishment Of Centrosome Localization
Maintenance Of Centrosome Location
Auditory Receptor Cell Development
Positive Regulation Of Dendritic Spine Morphogenesis
Regulation Of Microtubule Cytoskeleton Organization
Cochlea Development
Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity
Myeloid Leukocyte Migration
Regulation Of Postsynapse Organization
Radial Glia-guided Pyramidal Neuron Migration
Interneuron Migration
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Nuclear Migration
Nervous System Development
Neuromuscular Junction Development
Centriole-centriole Cohesion
Ventral Spinal Cord Development
Positive Regulation Of Microtubule Polymerization
Melanosome Transport
Microtubule Anchoring At Centrosome
Retrograde Transport, Endosome To Golgi
Neuromuscular Process
Nuclear Membrane Disassembly
Cell Division
Regulation Of Mitotic Spindle Organization
Motor Behavior
Neuron Cellular Homeostasis
Positive Regulation Of Microtubule Nucleation
Axonal Transport
Maintenance Of Synapse Structure
Positive Regulation Of Neuromuscular Junction Development
Non-motile Cilium Assembly
Neuron Projection Maintenance
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
MHC class II antigen presentation
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-independent Golgi-to-ER retrograde traffic
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
Perry syndrome
Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
Distal hereditary motor neuropathies (dHMN)
GWAS
Adverse response to drug (
30420678
)
Anxiety (
33859377
)
Depression (
33859377
)
Mean platelet volume (
32888494
)
Neurociticism (
29500382
)
Neuroticism (
27089181
)
Self-reported tiredness (
28194004
)
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Refractive error (
32231278
)
Interacting Genes
26 interacting genes:
CLIP1
CRYAA
CSNK2A1
CUL4A
CUL4B
DAB1
DCTN1
DCTN2
DCX
DNAI1
FBXO7
HSPH1
KARS1
KATNA1
KATNB1
MAP1B
MAP2
NDE1
NDEL1
NUDC
PAFAH1B2
PAFAH1B3
PDE4D
SLC25A21-AS1
TNIK
TUBA1A
52 interacting genes:
ACTR1A
ACTR1B
AKT1
APEX1
BBS1
BBS4
BICD1
BICD2
CASP2
CASP3
CASP7
CDC37
CLIP1
CTIF
DCTN3
DISC1
DST
DTNBP1
DYNC1I1
DYNC1I2
EEF1A1
ENO3
FBXL5
FXR1
GRB2
GSK3B
HAP1
HOXA1
HSPB2
KIAA0408
KIF11
LCOR
MAP2K3
MAP2K6
MAPRE1
MED14
MTERF1
NEK2
NOD2
PAFAH1B1
PFDN1
PGAM1
PPP1CA
RAB6A
RBL2
RPGR
SEC23A
SPTBN2
STAT1
TP53RK
VIM
ZNF512B
Entrez ID
5048
1639
HPRD ID
03329
07206
Ensembl ID
ENSG00000007168
ENSG00000204843
Uniprot IDs
A0A6Q8PFT2
A0A6Q8PFU3
P43034
A0A7P0Z4C3
Q14203
PDB IDs
7MT1
8DYU
8DYV
8FDT
8FDU
8PQW
8PQY
8PQZ
8PTK
1TXQ
2COY
2HKN
2HKQ
2HL3
2HL5
2HQH
3E2U
3TQ7
Enriched GO Terms of Interacting Partners
?
Microtubule
Microtubule Cytoskeleton Organization
Microtubule-based Process
Microtubule Binding
Cytoskeleton
Cytoskeleton Organization
Microtubule Associated Complex
Organelle Localization
Cytosol
Cytoplasm
Neuron Migration
Establishment Of Organelle Localization
Chromosome Localization
Centrosome
Regulation Of Microtubule Polymerization Or Depolymerization
Organelle Organization
Microtubule-based Transport
Spindle
Nervous System Development
Microtubule-based Movement
Microtubule Cytoskeleton Organization Involved In Mitosis
Microtubule Cytoskeleton
Neuron Projection Morphogenesis
Regulation Of Neuron Projection Development
Regulation Of Microtubule Polymerization
Cell Projection Morphogenesis
Regulation Of Microtubule Cytoskeleton Organization
Kinetochore
Transport Along Microtubule
Platelet-activating Factor Acetyltransferase Activity
1-alkyl-2-acetylglycerophosphocholine Esterase Complex
Organelle Transport Along Microtubule
Cytoskeleton-dependent Intracellular Transport
Protein Heterodimerization Activity
Positive Regulation Of Microtubule Polymerization
Establishment Of Vesicle Localization
Dynein Complex
Establishment Of Mitotic Spindle Orientation
Basal Dendrite
Katanin Complex
Radial Glia-guided Pyramidal Neuron Migration
Establishment Of Mitotic Spindle Localization
Vesicle Localization
Mitotic Centrosome Separation
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Dendrite Development
Establishment Of Spindle Orientation
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Regulation Of Microtubule-based Process
Axon Hillock
Cytosol
Centrosome
Microtubule-based Process
Transport Along Microtubule
Cytoskeleton
Cytoskeleton-dependent Intracellular Transport
Dynactin Binding
Microtubule-based Transport
Cytoplasm
Organelle Transport Along Microtubule
Microtubule-based Movement
Cytoskeleton Organization
Organelle Organization
Minus-end-directed Organelle Transport Along Microtubule
Protein Kinase Binding
Regulation Of Microtubule-based Process
Microtubule Cytoskeleton Organization
Establishment Of Organelle Localization
Microtubule Plus-end Binding
Microtubule Organizing Center
Execution Phase Of Apoptosis
Microtubule
Cell Cortex
Dynactin Complex
Organelle Assembly
Hippocampus Development
Positive Regulation Of Cilium Assembly
Axon
Ciliary Basal Body
Response To Light Stimulus
Microtubule Anchoring At Microtubule Organizing Center
Positive Regulation Of Cellular Component Organization
Response To Radiation
Pyroptotic Inflammatory Response
Perinuclear Region Of Cytoplasm
Vesicle Transport Along Microtubule
Regulation Of Microtubule Cytoskeleton Organization
Organelle Localization
Microtubule Cytoskeleton
Establishment Of Vesicle Localization
Non-motile Cilium Assembly
Protein Binding
Central Region Of Growth Cone
Vesicle Cytoskeletal Trafficking
Brain Morphogenesis
Dynein Complex Binding
Retrograde Axonal Transport
Vesicle Localization
Protein Localization To Cilium
Regulation Of Cytoskeleton Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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