PAFAH1B1 and MAP1B

Number of citations of the paper that reports this interaction (PubMedID 15762842)
48

Data Source:
HPRD (in vivo, in vitro)

		PAFAH1B1	MAP1B
Description		platelet activating factor acetylhydrolase 1b regulatory subunit 1	microtubule associated protein 1B
Image			No pdb structure
GO Annotations	Cellular Component	Astral Microtubule Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Cell Leading Edge Motile Cilium Nuclear Membrane Vesicle Stereocilium Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Axon Cytoplasm	Photoreceptor Outer Segment Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Plasma Membrane Postsynaptic Density Axon Dendrite Growth Cone Somatodendritic Compartment Cell Projection Neuronal Cell Body Varicosity Dendritic Spine Perikaryon Synapse Perinuclear Region Of Cytoplasm Apical Dendrite Basal Dendrite Hippocampal Mossy Fiber Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding	Actin Binding Structural Molecule Activity Protein Binding Phospholipid Binding Microtubule Binding Protein-containing Complex Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Microtubule-based Process Nuclear Migration JNK Cascade Chemical Synaptic Transmission Germ Cell Development Nervous System Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Cell Migration Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Positive Regulation Of Cellular Component Organization Cell Division Establishment Of Localization In Cell Establishment Of Organelle Localization Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Myeloid Leukocyte Migration Regulation Of Postsynapse Organization Radial Glia-guided Pyramidal Neuron Migration Interneuron Migration	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Neuron Migration Negative Regulation Of Microtubule Depolymerization Nervous System Development Axonogenesis Synapse Assembly Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Carbohydrate Peripheral Nervous System Axon Regeneration Dendrite Development Response To Insecticide Developmental Maturation Regulation Of Microtubule Depolymerization Positive Regulation Of Microtubule Polymerization Neuron Projection Development Response To Nutrient Levels Response To Estradiol Negative Regulation Of Intracellular Transport Response To Vitamin A Positive Regulation Of Neuron Differentiation Positive Regulation Of Axon Extension Intracellular Transport Mitochondrion Transport Along Microtubule Neuron Development Axon Extension Response To Axon Injury Induction Of Synaptic Plasticity By Chemical Substance Establishment Of Monopolar Cell Polarity Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Odontoblast Differentiation Regulation Of Postsynapse Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	RSV-host interactions
Drugs
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)	Attention deficit hyperactivity disorder ( 18839057) Coronary artery disease in type 1 diabetes ( 29695241) Refractive error ( 32231278)
Interacting Genes		26 interacting genes: CLIP1 CRYAA CSNK2A1 CUL4A CUL4B DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D SLC25A21-AS1 TNIK TUBA1A	36 interacting genes: ACTB ANP32A ARHGEF11 CREBBP CSNK2A1 DYNLL1 EEF1D ERBB3 FOS GABRR1 GABRR2 GAN GSK3B HMGB1 HTR6 LRRK2 MAG MAGOH MAP1A MAPK8 MARCHF5 MINK1 NEIL3 NXF1 NXF2 PAFAH1B1 PRKAR1A RASSF1 RNF10 SNCA SPP1 STAU1 STRAP U2AF1 U2AF2 VHL
Entrez ID		5048	4131
HPRD ID		03329	01139
Ensembl ID		ENSG00000007168	ENSG00000131711
Uniprot IDs		A0A6Q8PFT2 A0A6Q8PFU3 P43034	A2BDK6 P46821 Q6PJD3 Q86X89
PDB IDs		7MT1 8DYU 8DYV 8FDT 8FDU 8PQW 8PQY 8PQZ 8PTK
Enriched GO Terms of Interacting Partners?		Microtubule Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule Binding Cytoskeleton Cytoskeleton Organization Microtubule Associated Complex Organelle Localization Cytosol Cytoplasm Neuron Migration Establishment Of Organelle Localization Chromosome Localization Centrosome Regulation Of Microtubule Polymerization Or Depolymerization Organelle Organization Microtubule-based Transport Spindle Nervous System Development Microtubule-based Movement Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Cytoskeleton Neuron Projection Morphogenesis Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Cell Projection Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Kinetochore Transport Along Microtubule Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Organelle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Protein Heterodimerization Activity Positive Regulation Of Microtubule Polymerization Establishment Of Vesicle Localization Dynein Complex Establishment Of Mitotic Spindle Orientation Basal Dendrite Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Establishment Of Mitotic Spindle Localization Vesicle Localization Mitotic Centrosome Separation Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendrite Development Establishment Of Spindle Orientation Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Axon Hillock	Tau Protein Binding Positive Regulation Of Cell Communication Cellular Response To Stress Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Microtubule Associated Complex Axon Regulation Of Norepinephrine Uptake Regulation Of Biological Quality JNK Cascade Intracellular Signaling Cassette Intracellular Signal Transduction Transporter Regulator Activity Regulation Of Autophagy Regulation Of Cellular Response To Stress Regulation Of Protein Localization Negative Regulation Of Gene Expression Synapse Glutamatergic Synapse Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Protein Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Chemical Synaptic Transmission Positive Regulation Of Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Pre-mRNA 3'-splice Site Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Trans-synaptic Signaling Synaptic Signaling Modulation Of Chemical Synaptic Transmission Nuclear RNA Export Factor Complex Negative Regulation Of Macromolecule Biosynthetic Process Response To Stress Substantia Nigra Development Regulation Of Apoptotic Process Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process
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