PAFAH1B1 and NUDC

Number of citations of the paper that reports this interaction (PubMedID 11734602)
0

Data Source:
HPRD (in vivo, in vitro)

		PAFAH1B1	NUDC
Description		platelet activating factor acetylhydrolase 1b regulatory subunit 1	nuclear distribution C, dynein complex regulator
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GO Annotations	Cellular Component	Astral Microtubule Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Cell Cortex 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Microtubule Cytoskeleton Membrane Axon Growth Cone Cell Leading Edge Motile Cilium Nuclear Membrane Vesicle Stereocilium Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Central Region Of Growth Cone Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Midbody Mitotic Spindle
	Molecular Function	Protein Binding Microtubule Binding Heparin Binding Dynactin Binding Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Protein Heterodimerization Activity Microtubule Plus-end Binding Phosphoprotein Binding Dynein Complex Binding	Protein Binding Cadherin Binding Unfolded Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Ameboidal-type Cell Migration Acrosome Assembly Neuron Migration Positive Regulation Of Cytokine-mediated Signaling Pathway Lipid Metabolic Process Microtubule-based Process Nuclear Migration JNK Cascade Chemical Synaptic Transmission Germ Cell Development Nervous System Development Neuroblast Proliferation Learning Or Memory Retrograde Axonal Transport Adult Locomotory Behavior Protein Secretion Negative Regulation Of Neuron Projection Development Lipid Catabolic Process Cell Migration Stem Cell Division Transmission Of Nerve Impulse Corpus Callosum Morphogenesis Hippocampus Development Layer Formation In Cerebral Cortex Cerebral Cortex Neuron Differentiation Cerebral Cortex Development Actin Cytoskeleton Organization Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Osteoclast Development Reelin-mediated Signaling Pathway Positive Regulation Of Embryonic Development Establishment Of Planar Polarity Of Embryonic Epithelium Cortical Microtubule Organization Positive Regulation Of Axon Extension Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of JNK Cascade Platelet Activating Factor Metabolic Process Vesicle Transport Along Microtubule Brain Morphogenesis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Microtubule Sliding Nuclear Membrane Disassembly Positive Regulation Of Cellular Component Organization Cell Division Establishment Of Localization In Cell Establishment Of Organelle Localization Establishment Of Centrosome Localization Maintenance Of Centrosome Location Auditory Receptor Cell Development Positive Regulation Of Dendritic Spine Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Cochlea Development Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Myeloid Leukocyte Migration Regulation Of Postsynapse Organization Radial Glia-guided Pyramidal Neuron Migration Interneuron Migration	Protein Folding Mitotic Spindle Organization Mitotic Metaphase Chromosome Alignment Nuclear Migration Response To Peptide Hormone Cell Division Establishment Of Organelle Localization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation RND2 GTPase cycle
Drugs			Phenethyl Isothiocyanate
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Adverse response to drug ( 30420678) Anxiety ( 33859377) Depression ( 33859377) Mean platelet volume ( 32888494) Neurociticism ( 29500382) Neuroticism ( 27089181) Self-reported tiredness ( 28194004)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Lipoprotein (a) levels ( 33730874) Plateletcrit ( 27863252)
Interacting Genes		26 interacting genes: CLIP1 CRYAA CSNK2A1 CUL4A CUL4B DAB1 DCTN1 DCTN2 DCX DNAI1 FBXO7 HSPH1 KARS1 KATNA1 KATNB1 MAP1B MAP2 NDE1 NDEL1 NUDC PAFAH1B2 PAFAH1B3 PDE4D SLC25A21-AS1 TNIK TUBA1A	8 interacting genes: ACD CEBPA NAGK OGT PAFAH1B1 PLK1 POT1 TINF2
Entrez ID		5048	10726
HPRD ID		03329	10122
Ensembl ID		ENSG00000007168	ENSG00000090273
Uniprot IDs		A0A6Q8PFT2 A0A6Q8PFU3 P43034	Q9Y266
PDB IDs		7MT1 8DYU 8DYV 8FDT 8FDU 8PQW 8PQY 8PQZ 8PTK	3QOR 7NDX
Enriched GO Terms of Interacting Partners?		Microtubule Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule Binding Cytoskeleton Cytoskeleton Organization Microtubule Associated Complex Organelle Localization Cytosol Cytoplasm Neuron Migration Establishment Of Organelle Localization Chromosome Localization Centrosome Regulation Of Microtubule Polymerization Or Depolymerization Organelle Organization Microtubule-based Transport Spindle Nervous System Development Microtubule-based Movement Microtubule Cytoskeleton Organization Involved In Mitosis Microtubule Cytoskeleton Neuron Projection Morphogenesis Regulation Of Neuron Projection Development Regulation Of Microtubule Polymerization Cell Projection Morphogenesis Regulation Of Microtubule Cytoskeleton Organization Kinetochore Transport Along Microtubule Platelet-activating Factor Acetyltransferase Activity 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Organelle Transport Along Microtubule Cytoskeleton-dependent Intracellular Transport Protein Heterodimerization Activity Positive Regulation Of Microtubule Polymerization Establishment Of Vesicle Localization Dynein Complex Establishment Of Mitotic Spindle Orientation Basal Dendrite Katanin Complex Radial Glia-guided Pyramidal Neuron Migration Establishment Of Mitotic Spindle Localization Vesicle Localization Mitotic Centrosome Separation Regulation Of Plasma Membrane Bounded Cell Projection Organization Dendrite Development Establishment Of Spindle Orientation Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule-based Process Axon Hillock	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Organelle Organization Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Microtubule Organizing Center Organization Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Protein Localization To Chromosome Chromosome Organization Regulation Of Telomere Maintenance Nuclear Membrane Disassembly Membrane Disassembly Telomere Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA-templated DNA Biosynthetic Process Regulation Of Cellular Component Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Intracellular Signal Transduction Establishment Of Mitotic Spindle Orientation Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Regulation Of Organelle Organization Protein Localization To Organelle Centrosome Cycle Nuclear Membrane Organization Microtubule Cytoskeleton
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