SCP2 and ACAA2

Number of citations of the paper that reports this interaction (PMID 10856712)
16

Data Source:
HPRD (in vitro)

		SCP2	ACAA2
Gene Name		sterol carrier protein 2	acetyl-CoA acyltransferase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Inner Membrane Extracellular Vesicular Exosome
	Molecular Function	Fatty-acyl-CoA Binding Receptor Binding Protein Binding Phosphatidylinositol Transporter Activity Cholesterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Oleic Acid Binding	Acetyl-CoA C-acyltransferase Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Peroxisome Organization Bile Acid Metabolic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Protein Localization To Plasma Membrane Lipid Hydroperoxide Transport	Fatty Acid Metabolic Process Cholesterol Biosynthetic Process Cellular Response To Hypoxia Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Metabolism of lipids and lipoproteins alpha-linolenic acid (ALA) metabolism alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
Drugs
Diseases
GWAS			HDL cholesterol ( 18193044)
Protein-Protein Interactions		8 interactors: ACAA2 ACOX1 CACNA1A CAV1 EHHADH PEX5 PITPNA TRIP13	3 interactors: APP SCP2 TERT
Entrez ID		6342	10449
HPRD ID		01700	10380
Ensembl ID		ENSG00000116171	ENSG00000167315
Uniprot IDs		B2R761 E9PLD1 P22307 Q59HG9	B3KNP8 K7EME0 P42765
PDB IDs		1QND 2C0L
Enriched GO Terms of Interacting Partners?		Fatty Acid Beta-oxidation Lipid Metabolic Process Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Metabolic Process Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Cellular Lipid Catabolic Process Organic Acid Metabolic Process Monocarboxylic Acid Metabolic Process Small Molecule Metabolic Process Lipid Modification Carboxylic Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Lipid Catabolic Process Peroxisome Organization Membrane Organization Mitochondrial Membrane Organization Protein Localization To Membrane Cerebellar Molecular Layer Development Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Oxygen Levels Lipid Homeostasis Membrane Depolarization Vestibular Nucleus Development Negative Regulation Of Protein Homotetramerization Nitric Oxide Homeostasis Neuromuscular Process Oxidation-reduction Process Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Protein Import Into Peroxisome Matrix, Translocation Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Cholesterol Homeostasis Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Gamma-aminobutyric Acid Secretion Negative Regulation Of Pinocytosis Caveolin-mediated Endocytosis Protein Localization To Basolateral Plasma Membrane Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Acetylcholine Secretion, Neurotransmission Mammary Gland Involution Organelle Organization Cytosolic Calcium Ion Homeostasis	Lipid Hydroperoxide Transport Positive Regulation Of Intracellular Cholesterol Transport Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Regulation Of Intracellular Cholesterol Transport Synaptic Growth At Neuromuscular Junction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Steroid Metabolic Process Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Telomere Formation Via Telomerase Telomere Maintenance Via Telomere Shortening Inositol Trisphosphate Biosynthetic Process Cellular Component Assembly Collateral Sprouting Axon Midline Choice Point Recognition Alcohol Metabolic Process Male Genitalia Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Axon Choice Point Recognition Inositol Phosphate Biosynthetic Process Telomere Assembly Regulation Of Mitotic Cell Cycle Inositol Trisphosphate Metabolic Process Posttranscriptional Regulation Of Gene Expression Neuron Remodeling Replicative Cell Aging Alpha-linolenic Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Telomere Maintenance Via Telomerase Regulation Of Cell Cycle Process Production Of SiRNA Involved In RNA Interference RNA Processing RNA Interference Progesterone Biosynthetic Process Replicative Senescence Cellular Copper Ion Homeostasis Genitalia Morphogenesis Positive Regulation Of Cholesterol Transport RNA-dependent DNA Replication Progesterone Metabolic Process C21-steroid Hormone Biosynthetic Process Bile Acid Biosynthetic Process Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Kinase Activity
Tagcloud ?		cannabinoid cannabinoids cb chemotactic chemotaxis clone confocal crosstalk cxcl12 cxcr4 cytoskeletal elucidation healing innovative jwh mcf7 metastasis mmtv modulate nt orthotopic p42 p44 possess psychoactive pymt syngenic tumorigenic wound	100microm 14mm 28mm 50microm acaa1 allocated blastocysts c9t11 cis12 cis9 cla conjugated cpt2 dmso embryos fasn igfbp2 igfbp4 linoleic mentioned periparturitional qpcr scd supplement t10c12 trans10 trans11 unsupplemented zygotes
Tagcloud (Difference) ?		cannabinoid cannabinoids cb chemotactic chemotaxis clone confocal crosstalk cxcl12 cxcr4 cytoskeletal elucidation healing innovative jwh mcf7 metastasis mmtv modulate nt orthotopic p42 p44 possess psychoactive pymt syngenic tumorigenic wound	100microm 14mm 28mm 50microm acaa1 allocated blastocysts c9t11 cis12 cis9 cla conjugated cpt2 dmso embryos fasn igfbp2 igfbp4 linoleic mentioned periparturitional qpcr scd supplement t10c12 trans10 trans11 unsupplemented zygotes
Tagcloud (Intersection) ?